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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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, and

Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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. 2020 ). Academic and industrial GLP-1R agonist programs have since undertaken a robust, iterative approach to optimizing Ex-4-based compounds, including some that demonstrate substantial signaling bias. As mentioned previously, Phe1-Ex-4 exhibits