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Division of Medical Oncology, University of Washington, Seattle, Washington, USA
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clearly substantially more complex and may be composed of mixtures of ARPC and NEPC cell types or include ‘amphicrine’ tumor cells that individually express both ARPC and NEPC programs ( Labrecque et al. 2019 , Brady et al. 2021 a ). There is also
UofL Superfund Research Center, University of Louisville, Louisville, Kentucky, USA
The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, Kentucky, USA
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& Holloway 2009 ). Furthermore, sex steroid hormones play a crucial role in defining the sexually dimorphic liver during both early life and puberty onset. In males, testosterones exert a ‘programming’ effect on the liver during the prenatal period, while
Telethon Kids Institute, Perth, Australia
Healthy Environments and Lives (HEAL) Network
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CS & Holmes MC 2019 The role of 11β-hydroxy steroid dehydrogenase Type 2 in glucocorticoid programming of affective and cognitive behaviours . Neuroendocrinology 109 257 – 265 . ( https://doi.org/10.1159/000499660 ) Sherris AR Baiocchi M Fendorf
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organoids recapitulate the developmental program of the early human placenta . Stem Cell Reports 11 537 – 551 . ( https://doi.org/10.1016/j.stemcr.2018.07.004 ) Ho L van Dijk M Chye STJ Messerschmidt DM Chng SC Ong S Yi LK Boussata S Goh
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BIO5 Institute, University of Arizona, Tucson, Arizona, USA
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based on microbial characteristics ( Liu et al. 2020 ). A similar program uses a machine learning algorithm to personalize dietary interventions for glucose tolerance using baseline gut microbial signatures in combination with diet and health
