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Department of Medicine, Monash University, Clayton, Victoria, Australia
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, we explore the spectrum of clinical manifestations of PA and their molecular basis with a shift from the traditional focus on the MR as a regulator of renal sodium–potassium exchange to a broader understanding of its role in the modulation of tissue
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indicating that GH acts on organs, tissues, and body systems beyond effects on growth and metabolism ( Ballesteros et al. 2000 ). Table 1 shows the widespread actions on the tissues and organs of various systems including the renal, cardiovascular
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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Introduction Angiotensin-converting enzyme 2 (ACE2) is a critical regulator of cardiovascular, respiratory, renal, and gastrointestinal physiology and pathology, through its actions as part of the renin–angiotensin system (RAS) and kallikrein
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as heart failure and renal disease impairing wound healing whilst at the same time DFU-associated changes such as chronic inflammation promoting premature onset of cardiovascular, renal and musculoskeletal disease in this high-risk patient group
Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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microenvironment (sub-renal grafting), stromal stimuli, and hormone environment, extended time to establishment (average time to first graft for MURAL PDXs is ~220 days) ( Risbridger et al. 2021 ). Once established as serial transplantable grafts, PDXs can be
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), hepcidin and ferroportin ( Roth et al. 2019 ). The primary stimulus to renal production of the cytokine, EPO, is hypoxia ( Bachman et al. 2014 ). Hepcidin inhibits absorption of iron in the gut by binding to the iron transporter ferroportin and
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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(HIF-1α) ( Xekouki et al. 2015 ). A deep intronic SDHC variant causing aberrant splicing has also been found in a large Australian kindred affected by all four SDHx -related tumours, namely: paraganglioma, PA, renal cell carcinoma and
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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experience symptoms with life-threatening potential including abdominal distension, vomiting and/or diarrhoea, respiratory complications, blood volume insufficiency and thickening, vascular thrombosis and renal failure ( Humaidan et al. 2016 ). A more
