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Emma Ahlqvist Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden

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Rashmi B Prasad Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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Leif Groop Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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had the lowest estimated glomerular filtration rate (eGFR) already at diabetes diagnosis and were thus already at increased risk of developing chronic kidney disease (CKD), macroalbuminuria and end-stage renal disease (ESRD). In the SDR cohort, SIRD

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Jennifer M Ikle Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA

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Anna L Gloyn Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Stanford Diabetes Research Center, Stanford University, Stanford, California, USA

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sodium-glucose transporter in the kidney ( SGLT2 ), therefore, patients with HNF1A-MODY have a low renal threshold for glucose ( Pontoglio et al. 2000 ). Functional studies have demonstrated that protein-truncating mutations result in

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Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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damage to the kidney in people with diabetes. Moreover, some of the immunosuppressive medications used in islet transplant recipients can cause renal impairment. The current clinical site for human islet grafts, the portal vein, leads to marked loss of

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