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Nathalie Marissal-Arvy INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Rachel Hamiani INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Emmanuel Richard INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Marie-Pierre Moisan INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Véronique Pallet INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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, France) and were used concomitantly in another study. In this study, 24 Wistar rats were used for retinol measurements only. Plasma collections were performed on age-matched Wistar and LOU/C rats for subsequent retinol assays. Weaning male LOU/C rats (3

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Eleonore Fröhlich
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Anja Witke
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Barbara Czarnocka
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Richard Wahl
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(TSH)-induced uptake of iodide and the release of organified iodine in normal human thyrocytes ( Namba et al. 1993 ). High concentrations of retinol also exert dedifferentiating effects on normal thyrocytes ( Fröhlich et al. 2001 ). These effects

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D. J. HEAF
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J. GLOVER
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In a single experiment, lasting for 18 months, male and female quail were exposed to an annual cycle of artificial photoperiod synchronized with sunrise and sunset, and their plasma levels of immunoreactive retinol-binding protein (IRBP) and LH were monitored at frequent intervals. Plasma levels of both IRBP and LH showed a repeating annual cycle with maximal levels during the spring/summer, the period of reproductive activity and highest rate of egg-laying, and minimal levels during the autumn/winter. Plasma levels of IRBP and LH were significantly, but only weakly, correlated with each other. The possible role of LH in the regulation of plasma IRBP during reproduction is discussed. Evidence is presented that the proportion of IRBP which does not carry retinol (retinol-binding apoprotein; apoRBP) varies throughout the female breeding cycle and that the high apoRBP concentration noted in the spring/summer period may be related to the deposition of retinol in the egg.

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D. J. HEAF
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M. EL-SAYED
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B. PHYTHIAN
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J. CARROLL
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J. GLOVER
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Variations in thyroxine-binding prealbumin (TBPA) and retinol-binding protein (RBP) concentrations in plasma were determined in Japanese quail subjected to a shortened solar lighting cycle lasting 4 months of real time. The concentration of TBPA varied inversely with the length of daily photoperiod up to 15 h (correlation coefficient r = −0·99) when a minimum level was reached of about 50% of that obtained under short days consisting of 8 h light: 16 h darkness (8L : 16D). A slight reversal in the concentration of TBPA occurred with photoperiods in excess of 16 h. The time-lag in response of the cyclic change in TBPA after the change in the lighting cycle was 8 days. The concentration of holoRBP, on the other hand, showed little change with photoperiods <15 h, but between 15 and 17·5 h it passed through peak values which were 24% and approximately 10% higher than the initial concentrations in female and male birds respectively. Total immunoreactive RBP concentrations in plasma peaked similarly in females but in males the apparent changes were not significant. The molar ratio of the two proteins (TBPA: RBP) which form a 1:1 complex in plasma also changed inversely with photoperiod from 1·6 on short (8L : 16D) to 0·6 on long (16L : 8D) days. When the ratio declined below 1·0 it was noted that rapid growth of the gonads took place and when this ratio returned to > 1·0 regression set in. The changes in plasma TBPA concentration were examined in Japanese quail subjected to sudden changes in photoperiod from short (8L : 16D) to long (20L : 4D) days and vice versa. In the group of birds transferred from short to long days the plasma level declined significantly (P<0·05) within 3 days, whereas birds changed from long to short days were more refractory in that a significant increase was seen only after 30 days. The synthesis of TBPA in liver is closely controlled by photoperiod and it seems that this protein plays an important role in the peripheral distribution of thyroxine and perhaps also influences the cyclical supply of retinol to the gonads.

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K H Liu
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J C Huang
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J D Godkin
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Abstract

Caprine chorion, allantois and amnion from days 23, 28, 35, 39 and 45, and yolk sac from day 23 of pregnancy were isolated by dissection and cultured for 24 h in modified minimum essential medium in the presence of [35S] methionine. De novo-synthesized proteins released into the culture medium were analyzed by two-dimensional PAGE and fluorography. Patterns of protein production by these isolated extraembryonic membranes remained relatively unchanged from days 23 to 45 of pregnancy. Electrophoretic profiles of proteins synthesized by allantois and amnion were identical but distinct from that produced by chorion. Yolk sac was the major source of serum-like proteins. An acidic (pI 5·3–6·3) 22 kDa protein, which consisted of four isoelectric variants, was produced by all extraembryonic membranes and demonstrated to immunoreact with antiserum produced against bovine placental retinol-binding protein (RBP). Limited N-terminal sequence analysis of one major isoform indicated that the protein had complete homology with bovine RBP over the first 15 amino acids. Immunoreactive RBP was localized in epithelial cells lining the chorion, allantois and amnion. In this study, we have characterized and compared protein production by isolated extraembryonic membranes through days 23 to 45 of pregnancy and identified the 22 kDa protein as caprine RBP of placental origin.

Journal of Endocrinology (1995) 146, 527–534

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Yanwen Jiang College of Animal Sciences, Jilin University, Changchun, Jilin, China

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Lu Chen College of Animal Sciences, Jilin University, Changchun, Jilin, China

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Robert N Taylor Departments of Obstetrics and Gynecology and Molecular Medicine and Translational Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

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Chunjin Li College of Animal Sciences, Jilin University, Changchun, Jilin, China

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Xu Zhou College of Animal Sciences, Jilin University, Changchun, Jilin, China

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of decidualization in the estrogen-primed endometrium, other factors, including prostaglandins, prolactin, growth factors and extracellular matrix proteins, are important. Retinoic acid (RA), the physiological active metabolite of vitamin A (retinol

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Tracy Josephs Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

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Hayley Waugh Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

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Ilona Kokay Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

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David Grattan Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

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Mary Thompson Departments of Biochemistry and
Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, PO Box 56, Dunedin 9054, New Zealand

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and retinol-binding protein 4 (RBP4), are also expressed in a nutritionally dependent manner or have been implicated in some way with the state of insulin resistance. FIAF, also known as angiopoietin-like protein 4, was initially discovered as a novel

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Le Bu
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Qian Yao Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Zhimin Liu Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Wei Tang Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Junjie Zou Department of Endocrinology, Key Laboratory of Sichuan Province of Medicinal Chemistry, Department of Endocrinology, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China

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Shen Qu
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kit from Promega Corporation. The insulin ELISA kit from Mercodia, Uppsala, Sweden. GLUT4 and pAS160 antibodies from Santa Cruz Biotechnology, Inc. Rat retinol-binding protein 4 (RBP4) ELISA kit and secondary anti-rabbit antibody was obtained from Uscn

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Lili Guo Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China

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Penghua Fang Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China

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Mei Yu Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China

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Mingyi Shi Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China

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Ping Bo Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China
Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China

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Zhenwen Zhang Department of Endocrinology, Medical College, Department of Physiology, Department of Physical Education, Clinical Medical College, Yangzhou University, Nantong West Street No. 98, Yangzhou, Jiangsu 225001, China

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). Retinol-binding protein 4 (RBP4) and adiponectin ELISA kits were obtained from Uscn Life Science (Wuhan, China). Ala6–25Cys (SSPFPPRPTRAGRETQLLRSC) were custom synthesized by GL Biochem (Shanghai, China). Animals and i.c.v. injection All animal procedures

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Camilla Alexanderson
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Elias Eriksson Department of Physiology, Department of Pharmacology, Wallenberg Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University, Box 434, SE-405 30 Göteborg, Sweden

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Elisabet Stener-Victorin
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Malin Lönn Department of Physiology, Department of Pharmacology, Wallenberg Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University, Box 434, SE-405 30 Göteborg, Sweden

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Agneta Holmäng
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plasma levels of monocyte chemoattractant protein-1 (MCP-1) at 9 weeks of age and retinol binding protein-4 (RBP4) and soluble intercellular adhesion molecule-1 (sICAM 1) at 12 weeks of age. At 14–16 weeks of age, insulin sensitivity was measured with a

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