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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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reduction to DHT, a more potent AR analogue and being aromatised to oestradiol (E2), which acts via oestrogen receptors (ERs). These sex steroid receptors are ligand-dependent transcription factors, and AR and ERs, upon binding of their cognate hormone, are

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Ken KY Ho Garvan Institute of Medical Research, St. Vincent’s Hospital and the UNSW Sydney, Sydney, New South Wales, Australia

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Anthony J O’Sullivan St. George Hospital and the Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia

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Morton G Burt Southern Adelaide Diabetes and Endocrine, Flinders Medical Centre and College of Medicine and Public Health, and Flinders University, Adelaide, South Australia, Australia

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patient with GHD. The most relevant are the thyroid, adrenal and gonadal axes ( Table 2 ). Our laboratory has had a major interest in characterising the interactions between sex steroids and the GH system and their clinical significance. Androgens and

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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-CoV-2, severe acute respiratory syndrome coronavirus 2. In contrast, exposure to the male sex steroid, testosterone, elevated ACE2 protein levels in airway smooth muscle cells, irrespective of sex ( Kalidhindi et al. 2020 ). Given that ACE2

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Jun Yang Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, Monash University, Clayton, Victoria, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Discovery & Preclinical Domain, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Timothy J Cole Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Peter J Fuller Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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. ( https://doi.org/10.1161/HYPERTENSIONAHA.115.05981 ) Bienvenu LA Bell JR Weeks KL Delbridge LMD & Young MJ 2022 New perspectives on sex steroid and mineralocorticoid receptor signaling in cardiac ischemic injury . Frontiers in Physiology 13

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Adam Hagg School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Eliza O’Shea School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Craig A Harrison Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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Kelly L Walton School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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including inhibin A/B, in addition to the sex steroids oestradiol and progesterone. Significantly, ovarian inactivation is associated with the onset of numerous, often debilitating, physiological insults in women including disrupted metabolism, accelerated

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