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reduction to DHT, a more potent AR analogue and being aromatised to oestradiol (E2), which acts via oestrogen receptors (ERs). These sex steroid receptors are ligand-dependent transcription factors, and AR and ERs, upon binding of their cognate hormone, are
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patient with GHD. The most relevant are the thyroid, adrenal and gonadal axes ( Table 2 ). Our laboratory has had a major interest in characterising the interactions between sex steroids and the GH system and their clinical significance. Androgens and
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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-CoV-2, severe acute respiratory syndrome coronavirus 2. In contrast, exposure to the male sex steroid, testosterone, elevated ACE2 protein levels in airway smooth muscle cells, irrespective of sex ( Kalidhindi et al. 2020 ). Given that ACE2
Department of Medicine, Monash University, Clayton, Victoria, Australia
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. ( https://doi.org/10.1161/HYPERTENSIONAHA.115.05981 ) Bienvenu LA Bell JR Weeks KL Delbridge LMD & Young MJ 2022 New perspectives on sex steroid and mineralocorticoid receptor signaling in cardiac ischemic injury . Frontiers in Physiology 13
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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including inhibin A/B, in addition to the sex steroids oestradiol and progesterone. Significantly, ovarian inactivation is associated with the onset of numerous, often debilitating, physiological insults in women including disrupted metabolism, accelerated