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Renea A Taylor Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia
Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia

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Mitchell G Lawrence Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia

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Gail P Risbridger Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia

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adult stroma ( Cunha et al. 2002 ). We employed this remarkable instructive property of developmental mesenchyme to direct the differentiation of human embryonic stem cells into mature prostate epithelia ( Taylor et al. 2006 ). We subsequently learnt

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Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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. Mesenchymal stem cell GR knockout (Dermo1-Cre) Mesenchymal stem cells are multipotent progenitor cells typically located in the bone marrow that can differentiate into a variety of cell types including chondrocytes, osteoblasts, osteocytes, adipocytes, and

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Sunita M C De Sousa Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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Nèle F Lenders Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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Lydia S Lamb Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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Warrick J Inder Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia
Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia

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Ann McCormack Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia

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determined by transcription factor (TF) and hormonal immunohistochemistry. TFs drive maturation from pituitary stem cells: pituitary-specific POU-class homeodomain transcription factor (PIT-1) gives rise to acidophil cells; steroidogenic factor 1 (SF1) gives

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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derived from embryonic stem cells ( Samuel et al. 2020 ). On the other hand, dutasteride reduced SARS-CoV-2 virus internalisation in human primary alveolar epithelial cells and anti-androgens reduced ACE2 expression and virus infection of lung epithelial

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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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muscle progenitor cells and muscle protein synthesis and inhibits adipogenic differentiation of pluripotent stem cells ( Herbst & Bhasin 2004 ). Testosterone, following aromatisation to E2, increases growth hormone (GH) secretion from the pituitary

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Adam Hagg School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Eliza O’Shea School of Biomedical Sciences, University of Queensland, Brisbane, Australia

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Craig A Harrison Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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Kelly L Walton School of Biomedical Sciences, University of Queensland, Brisbane, Australia
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia

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/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy . Cell Stem Cell 9 433 – 446 . ( https://doi.org/10.1016/j.stem.2011.10.001 ) 22056140 Lotinun S Pearsall RS Davies MV

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