Search Results

You are looking at 1 - 10 of 1,205 items for :

  • "transcription factor" x
  • Refine by access: All content x
Clear All
David W Scoville Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

Search for other papers by David W Scoville in
Google Scholar
PubMed
Close
,
Kristin Lichti-Kaiser Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

Search for other papers by Kristin Lichti-Kaiser in
Google Scholar
PubMed
Close
,
Sara A Grimm Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

Search for other papers by Sara A Grimm in
Google Scholar
PubMed
Close
, and
Anton M Jetten Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

Search for other papers by Anton M Jetten in
Google Scholar
PubMed
Close

these results to publicly available data on the genomic binding of several other islet-enriched transcription factors, in order to determine whether GLIS3 regulates pancreatic beta cell gene transcription by binding to distinct regulatory hubs with other

Free access
Robert S Viger Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

Search for other papers by Robert S Viger in
Google Scholar
PubMed
Close
,
Marie France Bouchard Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada

Search for other papers by Marie France Bouchard in
Google Scholar
PubMed
Close
, and
Jacques J Tremblay Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

Search for other papers by Jacques J Tremblay in
Google Scholar
PubMed
Close

STAR gene has been proposed to be regulated by a multitude of DNA-binding and/or -associating transcription factors ( Fig. 1 ), working alone or in combination ( Fig. 2 ), and that interact with regulatory sequences in the STAR promoter with either

Restricted access
Dominique A Glauser Fondation pour Recherches Médicales, University of Geneva, Av. de la Roseraie 64, 1211 Geneva, Switzerland

Search for other papers by Dominique A Glauser in
Google Scholar
PubMed
Close
and
Werner Schlegel Fondation pour Recherches Médicales, University of Geneva, Av. de la Roseraie 64, 1211 Geneva, Switzerland

Search for other papers by Werner Schlegel in
Google Scholar
PubMed
Close

Part I: introduction to FOXO transcription factors Classification and structure of FOXO proteins FOXO transcription factors form a subclass of the large family of Forkhead proteins characterized by the

Free access
Chunchun Wei Department of Pathophysiology, Naval Medical University, Shanghai, China
Department of Physiology, Naval Medical University, Shanghai, China

Search for other papers by Chunchun Wei in
Google Scholar
PubMed
Close
,
Xianhua Ma Department of Pathophysiology, Naval Medical University, Shanghai, China

Search for other papers by Xianhua Ma in
Google Scholar
PubMed
Close
,
Kai Su Department of Pathophysiology, Naval Medical University, Shanghai, China

Search for other papers by Kai Su in
Google Scholar
PubMed
Close
,
Shasha Qi Department of Pathophysiology, Naval Medical University, Shanghai, China

Search for other papers by Shasha Qi in
Google Scholar
PubMed
Close
,
Yuangang Zhu The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China

Search for other papers by Yuangang Zhu in
Google Scholar
PubMed
Close
,
Junjian Lin Department of Pathophysiology, Naval Medical University, Shanghai, China

Search for other papers by Junjian Lin in
Google Scholar
PubMed
Close
,
Chenxin Wang The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China

Search for other papers by Chenxin Wang in
Google Scholar
PubMed
Close
,
Rui Yang Department of Pathophysiology, Naval Medical University, Shanghai, China

Search for other papers by Rui Yang in
Google Scholar
PubMed
Close
,
Xiaowei Chen The State Key Laboratory of Membrane Biology, Center for Life Sciences and Institute of Molecular Medicine, Peking University, Beijing, China

Search for other papers by Xiaowei Chen in
Google Scholar
PubMed
Close
,
Weizhong Wang Department of Physiology, Naval Medical University, Shanghai, China

Search for other papers by Weizhong Wang in
Google Scholar
PubMed
Close
, and
Weiping J Zhang Department of Pathophysiology, Naval Medical University, Shanghai, China
NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin, China

Search for other papers by Weiping J Zhang in
Google Scholar
PubMed
Close

. Carbohydrate response element-binding protein (ChREBP) is one of the key transcription factors regulating DNL in liver and intestine ( Iizuka et al . 2004 , Kim et al . 2016 , 2017 , Liu et al . 2017 , Shi et al . 2020 ). Although ChREBP is also

Restricted access
Michael Mannstadt Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

Search for other papers by Michael Mannstadt in
Google Scholar
PubMed
Close
,
Emily Holick Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

Search for other papers by Emily Holick in
Google Scholar
PubMed
Close
,
Wenping Zhao Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

Search for other papers by Wenping Zhao in
Google Scholar
PubMed
Close
, and
Harald Jüppner Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA
Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

Search for other papers by Harald Jüppner in
Google Scholar
PubMed
Close

orthologs of the Drosophila gene glial cells missing) is a transcription factor which is exclusively expressed during embryonic development in the parathyroid-specific domain that later gives rise to the parathyroid glands ( Kim et al . 1998 , Günther

Free access
Débora Cristina de Moraes
Search for other papers by Débora Cristina de Moraes in
Google Scholar
PubMed
Close
,
Mario Vaisman Laboratório de Endocrinologia Molecular, Hospital Universitário Clementino Fraga Filho, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Rio de Janeiro CEP 21949-900, Brasil

Search for other papers by Mario Vaisman in
Google Scholar
PubMed
Close
,
Flavia Lucia Conceição Laboratório de Endocrinologia Molecular, Hospital Universitário Clementino Fraga Filho, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Rio de Janeiro CEP 21949-900, Brasil

Search for other papers by Flavia Lucia Conceição in
Google Scholar
PubMed
Close
, and
Tânia Maria Ortiga-Carvalho
Search for other papers by Tânia Maria Ortiga-Carvalho in
Google Scholar
PubMed
Close

( Kioussi et al . 1999 ), Tpit ( Lamolet et al . 2001 ) and Prop1 ( Sornson et al . 1996 ). Figure 2 Temporal and spatial activation of pituitary transcription factors. In response to the BMP2–FGF8 ventral–dorsal gradient, pituitary cell lineages are

Free access
Jinke Wang The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

Search for other papers by Jinke Wang in
Google Scholar
PubMed
Close
,
Jie Lu The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

Search for other papers by Jie Lu in
Google Scholar
PubMed
Close
,
Guangming Gu The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

Search for other papers by Guangming Gu in
Google Scholar
PubMed
Close
, and
Yingxun Liu The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

Search for other papers by Yingxun Liu in
Google Scholar
PubMed
Close

Introduction Transcription factors (TFs) are central to almost every fundamental cellular process ( Latchman 2008 , Ladunga 2010 ) and account for ∼5–10% of genes in eukaryotes ( Reece-Hoyes et al . 2005 , Adryan & Teichmann 2006 , Ho et al

Free access
L Grinius Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

Search for other papers by L Grinius in
Google Scholar
PubMed
Close
,
C Kessler Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

Search for other papers by C Kessler in
Google Scholar
PubMed
Close
,
J Schroeder Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

Search for other papers by J Schroeder in
Google Scholar
PubMed
Close
, and
S Handwerger Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

Search for other papers by S Handwerger in
Google Scholar
PubMed
Close

Introduction Transcription factors of the forkhead (FOXO) family of DNA-binding proteins are involved in regulation of diverse cellular functions, such as differentiation, metabolism, proliferation, and survival (for review see

Free access
Eric W-F Lam Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

Search for other papers by Eric W-F Lam in
Google Scholar
PubMed
Close
,
Kunal Shah Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

Search for other papers by Kunal Shah in
Google Scholar
PubMed
Close
, and
Jan J Brosens Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

Search for other papers by Jan J Brosens in
Google Scholar
PubMed
Close

of intense tissue remodelling. Among these factors are members of the FOXO family of transcription factors. FOXO proteins, functioning downstream of the phosphoinositol-3-kinase (PI3K)/AKT oncogenic signalling pathway, are central to a diversity of

Free access
Zhihao Liu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Zhihao Liu in
Google Scholar
PubMed
Close
,
Fengrui Wu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Fengrui Wu in
Google Scholar
PubMed
Close
,
Baowei Jiao Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Baowei Jiao in
Google Scholar
PubMed
Close
,
Xiuyue Zhang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Xiuyue Zhang in
Google Scholar
PubMed
Close
,
Chongjiang Hu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Chongjiang Hu in
Google Scholar
PubMed
Close
,
Baofeng Huang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Baofeng Huang in
Google Scholar
PubMed
Close
,
Linyan Zhou Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Linyan Zhou in
Google Scholar
PubMed
Close
,
Xigui Huang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Xigui Huang in
Google Scholar
PubMed
Close
,
Zhijian Wang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Zhijian Wang in
Google Scholar
PubMed
Close
,
Yaoguang Zhang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Yaoguang Zhang in
Google Scholar
PubMed
Close
,
Yoshitaka Nagahama Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Yoshitaka Nagahama in
Google Scholar
PubMed
Close
,
Christopher H K Cheng Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Christopher H K Cheng in
Google Scholar
PubMed
Close
, and
Deshou Wang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Search for other papers by Deshou Wang in
Google Scholar
PubMed
Close

Introduction The doublesex and mab-3 (DM)-related transcription factor 1 ( Dmrt1 ) belongs to the DM domain gene family. Among the different phyla of the animal kingdom including vertebrates, it is the only gene found to be conserved

Free access