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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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glucocorticoid receptor is a ligand-dependent transcription factor that mediates the diverse actions of glucocorticoids in nearly all tissues due to its ubiquitous expression in nucleated cells. The GR belongs to the nuclear receptor subfamily and has four
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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determined by transcription factor (TF) and hormonal immunohistochemistry. TFs drive maturation from pituitary stem cells: pituitary-specific POU-class homeodomain transcription factor (PIT-1) gives rise to acidophil cells; steroidogenic factor 1 (SF1) gives
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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intracellular signalling cascade involving the phosphorylation of SMAD2 and SMAD3 transcription factors, their interaction with SMAD4 and translocation into the nucleus ( Massagué et al. 2005 ). Evidence also supports that activin B can also activate the
Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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receptor, including the AR, alpha-methylacyl-CoA racemase (AMACR), PSA, ETS transcription factor ERG (ERG) and neuroendocrine markers, and RNA sequencing and targeted DNA sequencing have been used to classify PDXs. Several PDXs have at least partial loss or
Department of Medicine, Monash University, Clayton, Victoria, Australia
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unstructured ( Kumar & McEwan 2012 ), enabling a broad range of interactions with other transcription factors and the transcription complex, with this activity designated (trans)activation function-1 (AF-1). A functional interaction has been described between
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reduction to DHT, a more potent AR analogue and being aromatised to oestradiol (E2), which acts via oestrogen receptors (ERs). These sex steroid receptors are ligand-dependent transcription factors, and AR and ERs, upon binding of their cognate hormone, are
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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transcription factors governs androgen receptor-dependent prostate cancer growth . Molecular Cell 27 380 – 392 . ( https://doi.org/10.1016/j.molcel.2007.05.041 ) Wang S Guo F Liu K Wang H Rao S Yang P & Jiang C 2008 Endocytosis of the receptor
