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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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, and

Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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functional receptors in engineered cell lines report dose-dependent elevations in cAMP accumulation as well as elevated intracellular calcium levels ( Dillon et al. 1993 ). This report teased a possible contribution of phospholipase C (PLC) to GLP-1