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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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phosphorylation (i.e. activation) of mitogen-activated protein kinase (MAPK, i.e. extracellular signal regulated kinase, ERK), a known PLC-activating cascade ( Montrose-Rafizadeh et al. 1999 ). Data in native human and mouse pancreatic islets conclusively