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MAPK signaling x

100 years of insulin: A special collection x

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100 YEARS OF INSULIN: A brief history of diabetes genetics: insights for pancreatic beta-cell development and function

Jennifer M Ikle

Jennifer M Ikle Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA

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Anna L Gloyn

Anna L Gloyn Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Stanford Diabetes Research Center, Stanford University, Stanford, California, USA

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variety of monogenic diabetes is unusual as it does not appear to directly involve defects in the β-cell rather it involves the acinar cells of the pancreas and may involve defects in mitogen-activating protein kinase (MAPK) signaling ( Ræder et al. 2014