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Rachel K Meyer School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA

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Frank A Duca School of Animal and Comparative Biomedical Sciences, College of Agricultural and Life Sciences, University of Arizona, Tucson, Arizona, USA
BIO5 Institute, University of Arizona, Tucson, Arizona, USA

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kinase (MAPK)-p62-mTOR complex 1 (mTORC1) signaling axis ( Fig. 3 ) ( Koh et al. 2018 ). Interestingly, individuals with T2D and high blood glucose taking metformin have increased IMP levels, and the blood glucose lowering effect of metformin is blunted

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JOE-23-0019
Volume/Issue:
Volume 258: Issue 2
Free access
Jessica Milano-Foster Division of Animal Sciences, 245 Bond Life Sciences Center, 1201 Rollins Dr University of Missouri, Columbia, Missouri, USA

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Laura C Schulz Department of Obstetrics, Gynecology and Women’s Health, N610 Medical Sciences Building, Columbia, Missouri, USA

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pressure may be normalized by inhibition of renin–angiotensin signaling, and other signs of PE like proteinuria, renal damage, and elevated sFLT are absent ( Parchem et al. 2021 ). Gain of function models Unlike Stox1 knockout mice, pregnant

Article Type:
Review Article
Collections:
Rising Stars special collection
DOI:
https://doi.org/10.1530/JOE-23-0008
Volume/Issue:
Volume 258: Issue 1
Free access