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Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil
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these unequivocal effects on energy metabolism, 3,5-T2 might also affect the hypothalamus–pituitary–thyroid axis. Horst et al . (1995) have shown that 3,5-T2 treatment reduced serum thyroid-stimulating hormone (TSH) and thyroxine (T 4 ) levels as well
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The TSH receptor and its role in the thyroid The established biological function of the TSH receptor (TSHR) in the thyroid gland is to regulate synthesis and secretion of thyroid hormones from follicular thyroid cells; it also plays an important
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Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of
Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of
Department of Medicine, Molecular, Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA Departments of
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primarily from physical inactivity and a reduced resting metabolic rate by virtue of the accompanying dramatic elevations of thyroid-stimulating hormone (TSH) levels. Sub-clinical hypothyroidism, characterized by elevated TSH levels but normal thyroid
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Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil
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thyrotropin (TSH), featuring a primary thyroid hypofunction, as well as higher serum leptin in the suckling pups, at the end of nicotine exposure. Interestingly, these animals show a very quick recovery at weaning, because these parameters were normal. In
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uncleaved holoreceptors on the cell surface than seen in thyroid cells ( Misrahi et al. 1994 , Rapoport et al. 1998 ). Deletion of the cleaved region in the TSHR ectodomain does not affect TSH binding to, nor activation of, the TSHR ( Chazenbalk et al
Institute of Molecular Pharmacology, 13125 Berlin, Germany
INSERM U584, Hôpital Necker, 75006 Paris, France
Division of Endocrinology, Department of Internal Medicine, University of Ulm, 89081 Ulm, Germany
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Institute of Molecular Pharmacology, 13125 Berlin, Germany
INSERM U584, Hôpital Necker, 75006 Paris, France
Division of Endocrinology, Department of Internal Medicine, University of Ulm, 89081 Ulm, Germany
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Institute of Molecular Pharmacology, 13125 Berlin, Germany
INSERM U584, Hôpital Necker, 75006 Paris, France
Division of Endocrinology, Department of Internal Medicine, University of Ulm, 89081 Ulm, Germany
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Institute of Molecular Pharmacology, 13125 Berlin, Germany
INSERM U584, Hôpital Necker, 75006 Paris, France
Division of Endocrinology, Department of Internal Medicine, University of Ulm, 89081 Ulm, Germany
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Institute of Molecular Pharmacology, 13125 Berlin, Germany
INSERM U584, Hôpital Necker, 75006 Paris, France
Division of Endocrinology, Department of Internal Medicine, University of Ulm, 89081 Ulm, Germany
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Institute of Molecular Pharmacology, 13125 Berlin, Germany
INSERM U584, Hôpital Necker, 75006 Paris, France
Division of Endocrinology, Department of Internal Medicine, University of Ulm, 89081 Ulm, Germany
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Introduction The thyrotrophin receptor (TSH-R) belongs to the family of G protein-coupled receptors (GPCRs) containing seven transmembrane helices (TMH). Since 1994, activating germline mutations of the TSH-R have been identified as
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, although the purification and identification of thyroid-stimulating hormone (TSH) spanned several decades ( Magner 2014 ). Semi-purified TSH preparations from bovine pituitaries demonstrated a similar structure to other pituitary hormones. It is composed of
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Introduction The feedback regulation of TSH secretion by thyroid hormones is mediated by the binding of 3,3′,5′-triiodothyronine (T 3 ) to the TRβ2 receptor in the pituitary and hypothalamus ( Chiamolera & Wondisford 2009 ). The acute suppression of
Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey
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Introduction The TSH receptor or the thyrotropin receptor (TSHR) is usually expressed by thyroid cells. It is a G protein-coupled receptor and signals through cAMP and inositol triphosphate (IP 3 ) pathways ( Kursawe & Paschke 2000 , Davies et al
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It has been established in animals that anterior pituitary hormones control their own secretion by regulating at a hypothalamic level the release of their hypothalamic factors (Motta, Fraschini & Martini, 1969). If a negative 'short-feedback' of thyroid-stimulating hormone (TSH) on the hypothalamus exists in man, the high plasma TSH levels of untreated primary hypothyroidism should fall markedly after the administration of bovine TSH which shares the biological, but not the immunological, properties of human TSH. This report describes the effects of bovine TSH on human plasma TSH (H-TSH) levels in patients with primary hypothyroidism.
Twenty-seven patients with untreated primary hypothyroidism were studied, of whom 20 had been treated with 131I and four by subtotal thyroidectomy for thyrotoxicosis. The remaining three patients had spontaneous primary hypothyroidism. The diagnosis of primary hypothyroidism was made on clinical grounds and on the basis of a low serum protein-bound iodine (< 3·8 μg/100 ml),