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100 years of glucagon: Anniversary collection x

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Metabolic regulation of glucagon secretion

Sarah L Armour

Sarah L Armour Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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Jade E Stanley

Jade E Stanley Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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James Cantley

James Cantley Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, UK

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E Danielle Dean

E Danielle Dean Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA

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Jakob G Knudsen

Jakob G Knudsen Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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reduced glucagon granule exocytosis ( Liu et al. 2004 , MacDonald et al. 2007 , Vieira et al. 2007 , Zhang et al. 2013 , Gylfe 2016 ) ( Fig. 1 ). This could suggest that alpha cells rely on glucose to maintain intracellular ATP. However, unlike