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Wnt pathway x

100 years of glucagon: Anniversary collection x

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The human α cell in health and disease

Yasminye D Pettway

Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders

Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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, and

Marcela Brissova

Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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production and components of α cell transduction and secretory pathways are summarized in Fig. 3 . For an in-depth review on mechanisms of glucagon secretion and α cell nutrient sensing, we refer readers to the reviews by Gao et al. (2023) and Armour et