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Se-Min Kim The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Farhath Sultana The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Steven Sims The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Judit Gimenez-Roig The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Victoria Laurencin The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anusha Pallapati The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Satish Rojekar The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tal Frolinger The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Weibin Zhou The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anisa Gumerova The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anne Macdonald The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Vitaly Ryu The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Daria Lizneva The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Funda Korkmaz The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tony Yuen The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Mone Zaidi The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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of the Tshr in mice results in a low bone mass without affecting thyroid development and thyroid hormone secretion ( Abe et al. 2003 ). This study laid a firm foundation for over two decades of work that led to the discovery of diverse functions

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0377
Volume/Issue:
Volume 262: Issue 1
Restricted access
Maryam Iravani Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden

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Marie Lagerquist Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Claes Ohlsson Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Lars Sävendahl Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden

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Introduction Longitudinal bone growth takes place in the growth plate, consisting of three layers: resting zone, proliferative zone and the hypertrophic zone. Bone growth is regulated by estrogens, acting either indirectly via the GH

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0263
Volume/Issue:
Volume 232: Issue 3
Free access
Timothy J Dreyer Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Jacob AC Keen Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Leah M Wells Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Scott J Roberts Department of Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Introduction Sclerostin is a 22 kDa secreted glycoprotein encoded by the SOST gene. It is primarily expressed by osteocytes and plays a major role in bone homeostasis, affecting bone formation and bone remodelling through its role as a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0209
Volume/Issue:
Volume 257: Issue 2
Free access
R Dobie
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V E MacRae
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C Huesa
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R van't Hof Division of Developmental Biology, Institute of Ageing and Chronic Disease, Developmental Endocrinology Research Group, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, Scotland, UK

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S F Ahmed Division of Developmental Biology, Institute of Ageing and Chronic Disease, Developmental Endocrinology Research Group, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, Scotland, UK

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C Farquharson
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Roith et al . 2001 ). The intimate relationship between GH and IGF1 makes it difficult to deduce the relative contributions of systemic and locally derived IGF1 to bone accrual. While Ghr −/− mice have recognised changes in skeletal mass and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0292
Volume/Issue:
Volume 223: Issue 1
Open access
Bernard Freudenthal Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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John Logan Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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Sanger Institute Mouse Pipelines Mouse Pipelines, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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Peter I Croucher Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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Graham R Williams Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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J H Duncan Bassett Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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al . 2009 ). The most important risk factors for osteoporotic fracture are low bone mineral density (BMD) (clinically assessed by dual-energy X-ray absorptiometry (DEXA or DXA)), increasing age and history of fracture ( Johnell et al . 2005

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0258
Volume/Issue:
Volume 231: Issue 1
Open access
Cátia F Gonçalves Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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Qing-Jun Meng Wellcome Centre for Cell Matrix Research, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

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their precise spatial and temporal control. Remarkably, physiological functions such as longitudinal bone growth, bone remodelling, chondrocyte metabolism and cartilage matrix turnover exhibit 24-h rhythms, being controlled by the peripheral circadian

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0256
Volume/Issue:
Volume 243: Issue 3
Free access
M J Devlin Department of Anthropology, University of Michigan, Ann Arbor, Michigan, USA

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D J Brooks Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

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C Conlon Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

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M van Vliet Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

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L Louis Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

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C J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

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M L Bouxsein Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA

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Introduction Bone marrow adipose tissue (MAT) is a complex and dynamic depot that likely includes both constitutive and regulated cell populations ( Devlin & Rosen 2015 , Scheller et al . 2015 ). MAT accumulation is a normal component of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0473
Volume/Issue:
Volume 229: Issue 3
Free access
K A Staines
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A S Pollard
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I M McGonnell
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C Farquharson Comparative Biomedical Sciences, Roslin Institute and R(D)SVS, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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A A Pitsillides
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Introduction The transition of cartilage to bone is the basis by which all long bones form. This transition is tightly regulated to ensure both permissive foetal development through endochondral ossification and postnatal longitudinal growth at the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0276
Volume/Issue:
Volume 219: Issue 1
Open access
Soo Yeon Jang Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

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Kyung Mook Choi Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

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Introduction The world population is rapidly aging. Maintaining independence in daily living in old age is one of the main interests in geriatric medicine, and keeping the bones and muscles healthy is crucial to a longer health span

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0093
Volume/Issue:
Volume 262: Issue 3
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Lara H Sattgast Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Adam J Branscum Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Natali Newman Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA

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Steven W Gonzales Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA

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Mary Lauren Benton Department of Computer Science, Baylor University, Waco, Texas, USA

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Erich J Baker Department of Computer Science, Baylor University, Waco, Texas, USA

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Kathleen A Grant Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA

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Russell T Turner Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Urszula T Iwaniec Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

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Introduction Long-term, chronic alcohol consumption can lead to suppression of bone turnover, and rapid changes in biochemical markers of bone turnover have been observed within hours following acute alcohol intake. Specifically, in healthy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0075
Volume/Issue:
Volume 255: Issue 3
Restricted access