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Department of Medicine, Monash University, Clayton, Victoria, Australia
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inflammation, fibrosis and remodelling in the cardiorenal system, as well as roles in adipose tissue and brain. The appreciation of PA as a multi-system disease with tissue-specific pathophysiology that can be mitigated by MR blockade may lead to more vigilant
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demonstrated similar masculinisation programming windows for the male reproductive tract and sexually dimorphic brain development in a range of species including rats ( Welsh et al. 2008 , 2010 , Dean et al. 2012 ) and mice ( Ghahramani et al. 2014
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Kidney GFR, ECW, and vascular volume Bone Growth and turnover Liver Growth factors and substrate metabolism Fat Lipid utilisation Skin Exocrine function and hair growth Brain Neurogenesis ECW
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adherence is high, but even under optimal circumstances, engagement is variable and adherence wanes with time ( Fabricatore et al. 2009 ). Because sex steroid receptors are expressed in the brain, a motivational benefit of testosterone to increase
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dysregulated in type 1 diabetes patients with peripheral neuropathic pain . Brain, Behavior, and Immunity – Health 15 100283. ( https://doi.org/10.1016/j.bbih.2021.100283 ) Ochoa-Precoma R Pacheco-Soto BT Porchia LM Torres-Rasgado E Perez
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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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involving a significant decrease in elastin synthesis ( Li et al. 2013 ). Interestingly, however, apart from these severe effects on lung development, other tissues including the brain, heart, liver, bone, and cartilage appeared to have no developmental
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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a ). ACE2 can be found in most tissues and organs of the body, including the lung, cardiovascular system, gastrointestinal tract, renal system, brain and nervous system, liver, pancreas, gallbladder, as well as the male and female reproductive