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Jun Yang Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, Monash University, Clayton, Victoria, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Discovery & Preclinical Domain, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Timothy J Cole Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Peter J Fuller Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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inflammation, fibrosis and remodelling in the cardiorenal system, as well as roles in adipose tissue and brain. The appreciation of PA as a multi-system disease with tissue-specific pathophysiology that can be mitigated by MR blockade may lead to more vigilant

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Marilyn B Renfree School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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Geoff Shaw School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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demonstrated similar masculinisation programming windows for the male reproductive tract and sexually dimorphic brain development in a range of species including rats ( Welsh et al. 2008 , 2010 , Dean et al. 2012 ) and mice ( Ghahramani et al. 2014

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Ken KY Ho Garvan Institute of Medical Research, St. Vincent’s Hospital and the UNSW Sydney, Sydney, New South Wales, Australia

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Anthony J O’Sullivan St. George Hospital and the Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia

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Morton G Burt Southern Adelaide Diabetes and Endocrine, Flinders Medical Centre and College of Medicine and Public Health, and Flinders University, Adelaide, South Australia, Australia

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Kidney GFR, ECW, and vascular volume Bone Growth and turnover Liver Growth factors and substrate metabolism Fat Lipid utilisation Skin Exocrine function and hair growth Brain Neurogenesis ECW

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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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adherence is high, but even under optimal circumstances, engagement is variable and adherence wanes with time ( Fabricatore et al. 2009 ). Because sex steroid receptors are expressed in the brain, a motivational benefit of testosterone to increase

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Emma J Hamilton Medical School, University of Western Australia, Fiona Stanley Hospital, Murdoch and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

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Stephen M Twigg Central Clinical School, Sydney Medical School, the Faculty of Medicine and Health, University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

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dysregulated in type 1 diabetes patients with peripheral neuropathic pain . Brain, Behavior, and Immunity – Health 15 100283. ( https://doi.org/10.1016/j.bbih.2021.100283 ) Ochoa-Precoma R Pacheco-Soto BT Porchia LM Torres-Rasgado E Perez

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Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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involving a significant decrease in elastin synthesis ( Li et al. 2013 ). Interestingly, however, apart from these severe effects on lung development, other tissues including the brain, heart, liver, bone, and cartilage appeared to have no developmental

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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a ). ACE2 can be found in most tissues and organs of the body, including the lung, cardiovascular system, gastrointestinal tract, renal system, brain and nervous system, liver, pancreas, gallbladder, as well as the male and female reproductive

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