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Sarah J Richardson
Sarah J Richardson
Islet Biology Group, Exeter Centre for Excellence in Diabetes (EXCEED), Institute of Biomedical and Clinical Sciences (IBCS), University of Exeter, RILD Level 4, Exeter, UK
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Alberto Pugliese
Alberto Pugliese
Division of Diabetes Endocrinology and Metabolism, Departments of Medicine, Microbiology and Immunology, Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA
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obtained from organ donors more systematically. Starting in 1989, the Islet Transplantation Program in Belgium ( In’t Veld et al. 2007 ) and the Nordic Network for Islet Transplantation (Sweden 2007–2015) ( Wiberg et al. 2015 ) screened organ donors for
Wenjuan Liu
Wenjuan Liu
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Harry Kevin Lau
Harry Kevin Lau
Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada
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Dong Ok Son
Dong Ok Son
Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada
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Tianru Jin
Tianru Jin
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Advanced Diagnostics, Toronto General Research Institutes, University Health Network, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Division of Advanced Diagnostics, Toronto General Research Institutes, University Health Network, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Yehong Yang
Yehong Yang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Yiming Li
Yiming Li
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Gerald J Prud’homme
Gerald J Prud’homme
Department of Laboratory Medicine and Pathobiology, Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada
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Qinghua Wang
Qinghua Wang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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from the donor antemortem. Human islets were isolated by the University Health Network Islet Isolation Program, University of Toronto (No. 14-8321.2) ( Negi et al. 2012 , Purwana et al. 2014 , Batchuluun et al. 2018 ). The isolation protocol was
Lei Du
Lei Du
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
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The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
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Yang Wang
Yang Wang
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
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Cong-Rong Li
Cong-Rong Li
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
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Liang-Jian Chen
Liang-Jian Chen
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
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Jin-Yang Cai
Jin-Yang Cai
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
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Zheng-Rong Xia
Zheng-Rong Xia
Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China
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Wen-Tao Zeng
Wen-Tao Zeng
Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China
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Zi-Bin Wang
Zi-Bin Wang
Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China
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Xi-Chen Chen
Xi-Chen Chen
Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China
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Fan Hu
Fan Hu
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
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Dong Zhang
Dong Zhang
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China
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Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China
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Xiao-Wei Xing
Xiao-Wei Xing
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
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Zhi-Xia Yang
Zhi-Xia Yang
State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
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National Key Research and Development Program of China (Grant No: 2017YFC1001503) to Dong Zhang. Author contribution statement Zhi-Xia Yang, Xiao-Wei Xing, Dong Zhang, and Fan Hu designed the research. Zhi-Xia Yang also coordinated between authors
Nicole G Barra
Nicole G Barra
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Fernando F Anhê
Fernando F Anhê
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Joseph F Cavallari
Joseph F Cavallari
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Anita M Singh
Anita M Singh
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Darryl Y Chan
Darryl Y Chan
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Jonathan D Schertzer
Jonathan D Schertzer
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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acid receptor (RAR), which, after dimerization with retinoid X receptor (RXR), binds to retinoic acid-responsive elements (RARE) and regulates several transcriptional programs in various tissues ( Coates et al. 2010 ). Studies using pre
