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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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) and diabetes ( Del Prato et al. 2021 , Rosenstock et al. 2023 ), which are subject to potential regulation by signaling bias ( Zaïmia et al. 2023). Conversely, the opioid ( Ehrlich et al. 2019 , Gomes et al. 2020 , El Daibani et al