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Thomas Willmott Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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Elizabeth C Cottrell Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

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pregnancy, largely due to increased activity of the NOS enzymes within the vascular endothelium, under the control of estrogen ( Zullino et al. 2018 ). Impaired production and/or bioavailability of NOS-derived NO has been associated with poor pregnancy

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