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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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-mediated signaling bias achieved through modified amino acid sequence and fatty-acid acylation for peptide ligands, tailored chemical structures of small molecule ligands, and/or optimizations of physical chemistry of these pharmacological agents, (ii) structural