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fatty acid oxidation x

Insulin resistance and type 2 diabetes mellitus x

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In vivo techniques for assessment of insulin sensitivity and glucose metabolism

Margaret K Hahn

Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca

Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira

Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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). In healthy humans and rodents during the hyperinsulinemic euglycemic clamp, inhibition of EGP is accompanied by a robust decrease in plasma concentrations of glycerol and free fatty acids, which is due to inhibition of adipose tissue lipolysis by

Article Type:: Review Article

Collections:: Insulin resistance and type 2 diabetes mellitus

DOI:: https://doi.org/10.1530/JOE-23-0308

Volume/Issue:: Volume 260: Issue 3

Open access

In vivo models of gestational and type 2 diabetes mellitus characterized by endocrine pancreas cell impairments

Sandra K Szlapinski

Sandra K Szlapinski London, Ontario, Canada

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David J Hill

David J Hill Diabetes, Endocrinology and Metabolism, Lawson Health Research Institute, London, Ontario, Canada
Physiology and Pharmacology, Western University, London, Ontario, Canada

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-saturated fatty acid content being more obesogenic than short-chain fatty acids ( Hariri et al. 2010 ). Independent of calorific value, the addition of lipid at the expense of carbohydrate resulted in poorer glucose tolerance ( Takahashi et al. 1999

Article Type:: Review Article

Collections:: Insulin resistance and type 2 diabetes mellitus

DOI:: https://doi.org/10.1530/JOE-23-0317

Volume/Issue:: Volume 260: Issue 3

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Do adipocytes serve as a reservoir for severe acute respiratory syndrome coronavirus-2?

Charlotte Steenblock

Charlotte Steenblock Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Nicole Bechmann

Nicole Bechmann Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany

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Felix Beuschlein

Felix Beuschlein Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zürich, Switzerland

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Christian Wolfrum

Christian Wolfrum Department of Health Sciences and Technology, Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland

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Stefan R Bornstein

Stefan R Bornstein Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zürich, Switzerland
School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

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influence lipid metabolism in adipocytes, promoting the synthesis of lipids and fatty acids, as well as the formation of lipid droplets, while concurrently inhibiting fatty acid oxidation ( Hellerstein et al. 1993 , Amako et al. 2015 , Sanchez