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Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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). In healthy humans and rodents during the hyperinsulinemic euglycemic clamp, inhibition of EGP is accompanied by a robust decrease in plasma concentrations of glycerol and free fatty acids, which is due to inhibition of adipose tissue lipolysis by

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0308
Volume/Issue:
Volume 260: Issue 3
Open access
Sandra K Szlapinski London, Ontario, Canada

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David J Hill Diabetes, Endocrinology and Metabolism, Lawson Health Research Institute, London, Ontario, Canada
Physiology and Pharmacology, Western University, London, Ontario, Canada

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-saturated fatty acid content being more obesogenic than short-chain fatty acids ( Hariri et al. 2010 ). Independent of calorific value, the addition of lipid at the expense of carbohydrate resulted in poorer glucose tolerance ( Takahashi et al. 1999

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0317
Volume/Issue:
Volume 260: Issue 3
Restricted access
Charlotte Steenblock Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Nicole Bechmann Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany

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Felix Beuschlein Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zürich, Switzerland

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Christian Wolfrum Department of Health Sciences and Technology, Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland

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Stefan R Bornstein Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zürich, Switzerland
School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

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influence lipid metabolism in adipocytes, promoting the synthesis of lipids and fatty acids, as well as the formation of lipid droplets, while concurrently inhibiting fatty acid oxidation ( Hellerstein et al. 1993 , Amako et al. 2015 , Sanchez

Article Type:
Research Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0027
Volume/Issue:
Volume 258: Issue 2
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Aryane Cruz Oliveira Pinho CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

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Paula Laranjeira CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Flow Cytometry Unit, Department of Clinical Pathology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal
Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal

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Eugenia Carvalho CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Institute for Interdisciplinary Research, University of Coimbra (IIIUC), Casa Costa Alemão, Coimbra, Portugal
APDP-Portuguese Diabetes Association, Lisbon, Portugal

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. 2017 ). Moreover, this AT expansion leads to an increase in plasma free fatty acids and other lipid metabolites, that impair energetic homeostasis, insulin signaling, and immune-regulatory mechanisms, not only in AT but also systemically ( Agrawal et

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0242
Volume/Issue:
Volume 260: Issue 3
Restricted access