Search Results
Search for other papers by Marilyn B Renfree in
Google Scholar
PubMed
Search for other papers by Geoff Shaw in
Google Scholar
PubMed
the first demonstration of androgen imprinting in which exposure to the hormone during a short window of sensitivity caused later sexual differentiation events ( Fig. 5 ). We followed up by investigating the expression of the genes responsible for
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
Search for other papers by Sunita M C De Sousa in
Google Scholar
PubMed
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
Search for other papers by Nèle F Lenders in
Google Scholar
PubMed
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
Search for other papers by Lydia S Lamb in
Google Scholar
PubMed
Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
Search for other papers by Warrick J Inder in
Google Scholar
PubMed
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
Search for other papers by Ann McCormack in
Google Scholar
PubMed
Scaffold protein with multiple functions, including regulation of p27 expression and DNA replication and repair Inactivating mutations distributed throughout the gene Mostly frameshift, nonsense and missense mutations, less commonly splice site mutations
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
Search for other papers by Kirsty G Pringle in
Google Scholar
PubMed
Search for other papers by Lisa K Philp in
Google Scholar
PubMed
) showed a biphasic age-driven distribution of Ace2 in murine lungs and trachea across three different gene expression datasets ( Inde et al. 2021 ). First, there was a subtle biphasic distribution in two of the three datasets where lung and tracheal
Search for other papers by Adam Hagg in
Google Scholar
PubMed
Search for other papers by Eliza O’Shea in
Google Scholar
PubMed
Search for other papers by Craig A Harrison in
Google Scholar
PubMed
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
Search for other papers by Kelly L Walton in
Google Scholar
PubMed
.1101/gad.8.4.414 ) 8125256 Voutilainen R Eramaa M & Ritvos O 1991 Hormonally regulated inhibin gene expression in human fetal and adult adrenals . Journal of Clinical Endocrinology and Metabolism 73 1026 – 1030 . ( https://doi.org/10.1210/jcem-73
Search for other papers by Eugenie Macfarlane in
Google Scholar
PubMed
Search for other papers by Hong Zhou in
Google Scholar
PubMed
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
Search for other papers by Markus J Seibel in
Google Scholar
PubMed
, the ligand-bound GR can either act directly or indirectly on DNA to activate or repress target gene expression. There are three main proposed pathways that describe GR-mediated initiation of gene expression: transactivation, composite transactivation
Department of Medicine, Monash University, Clayton, Victoria, Australia
Search for other papers by Jun Yang in
Google Scholar
PubMed
Search for other papers by Morag J Young in
Google Scholar
PubMed
Search for other papers by Timothy J Cole in
Google Scholar
PubMed
Search for other papers by Peter J Fuller in
Google Scholar
PubMed
ENaC and, as a consequence, slows ENaC degradation ( Snyder et al. 2002 ). Regulation of ENaCα-subunit gene expression involves sgk-1 through relief of Dotla-Af9-mediated transcriptional repression ( Zhang et al. 2007 ). Nedd4-2 is also regulated by
Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Search for other papers by Renea A Taylor in
Google Scholar
PubMed
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Search for other papers by Mitchell G Lawrence in
Google Scholar
PubMed
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Search for other papers by Gail P Risbridger in
Google Scholar
PubMed
technical limitations to using PDXs in discovery research. For example, it is more challenging to perform mechanistic studies involving knockdown or over-expression of candidate genes using PDXs compared to cell lines. In vivo genetic screens have been
Search for other papers by Ken KY Ho in
Google Scholar
PubMed
Search for other papers by Anthony J O’Sullivan in
Google Scholar
PubMed
Search for other papers by Morton G Burt in
Google Scholar
PubMed
expression of genes promoting triglyceride storage ( Zhao et al. 2011 ). Moreover, GH inhibits lipoprotein lipase, the major enzyme responsible for the breakdown of triglycerides into free fatty acids prior to uptake by adipose tissue ( Richelsen et al
Search for other papers by Gary A Wittert in
Google Scholar
PubMed
Search for other papers by Mathis Grossmann in
Google Scholar
PubMed
Search for other papers by Bu B Yeap in
Google Scholar
PubMed
Search for other papers by David J Handelsman in
Google Scholar
PubMed
shuttled to the nucleus where they bind on specific DNA sequences (response elements), in gene promotor regions to regulate gene transcription in concert with transcriptional cofactors. In addition, there may be expression of cell membrane-bound sex steroid
Search for other papers by Emma J Hamilton in
Google Scholar
PubMed
Search for other papers by Stephen M Twigg in
Google Scholar
PubMed
was associated with increased expression of pro-inflammatory cytokines such as tumour necrosis factor α (TNFα), interleukin-1β (IL-1β) and IL-6, which in turn leads to increased expression of the receptor activator of nuclear factor κβ ligand (RANKL
