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Lauren Brady Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington, USA

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Peter S Nelson Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington, USA
Division of Medical Oncology, University of Washington, Seattle, Washington, USA

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hallmark gene expression patterns and genomic features of small-cell carcinoma, such as TP53 and RB1 loss ( Beltran et al. 2016 ), which are associated with poor outcomes for patients. Cell line experiments observed that restriction of REST activity

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Banrida Wahlang Department of Medicine, School of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Louisville, Louisville, Kentucky, USA
UofL Superfund Research Center, University of Louisville, Louisville, Kentucky, USA
The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, Kentucky, USA

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appreciated with mechanistic studies attributing the nature of growth hormone secretion, which is pulsatile in males and continuous in females, as a partial reason driving sexually dimorphic hepatic gene expression profiles ( Holloway et al. 2008 , Waxman

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Caitlin S Wyrwoll School of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia
Telethon Kids Institute, Perth, Australia
Healthy Environments and Lives (HEAL) Network

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subsequently induce changes in gene expression and protein activity in cells ( Horowitz 2002 , Sonna et al. 2002 ). To reduce the negative impacts of thermal stress on cells, genes associated with increased thermotolerance such as heat shock proteins are

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Rachel K Meyer School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA

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Frank A Duca School of Animal and Comparative Biomedical Sciences, College of Agricultural and Life Sciences, University of Arizona, Tucson, Arizona, USA
BIO5 Institute, University of Arizona, Tucson, Arizona, USA

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-1 and improved glucose tolerance ( Zhao et al. 2018 ). The impact of fiber on GLP-1 signaling could be due to increased number of L-cells or expression of the preproglucagon gene ( Massimino et al. 1998 , Everard et al. 2011 , Kaji et al

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Jessica Milano-Foster Division of Animal Sciences, 245 Bond Life Sciences Center, 1201 Rollins Dr University of Missouri, Columbia, Missouri, USA

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Laura C Schulz Department of Obstetrics, Gynecology and Women’s Health, N610 Medical Sciences Building, Columbia, Missouri, USA

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gene expression, defects which appear to precede embryonic cardiovascular phenotypes ( Freyer et al. 2017 , Ho et al. 2017 ). The transcription factor Stox1 was first implicated in PE in 2013 through gene association studies in the Netherlands

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