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Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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when β-cell dysfunction or loss leads to an inability to release enough insulin to control glucose. Other islet endocrine cell types include glucagon-secreting α-cells, δ-, pancreatic polypeptide (PP), and ε-cells. Insulin reduces blood glucose by

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Sarah J Richardson Islet Biology Group, Exeter Centre for Excellence in Diabetes (EXCEED), Institute of Biomedical and Clinical Sciences (IBCS), University of Exeter, RILD Level 4, Exeter, UK

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Alberto Pugliese Division of Diabetes Endocrinology and Metabolism, Departments of Medicine, Microbiology and Immunology, Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA

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. Figure 2 Representative histologically stained islets from type 1 diabetes pancreas. (A) An insulin-containing islet (ICI) with no evidence of immune cell infiltration (Insulin – brown; glucagon – pink, nPOD donor 6211). (B) An ICI with evidence of a

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