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. 1986 , Rouillé et al. 1994 ). In contrast, PC1/3 is highly enriched in intestinal L cells, where MPGF is further processed into glucagon-like peptide-1 (GLP-1), GLP-2, and oxyntomodulin ( Mojsov et al. 1986 ) ( Fig. 3A ). Figure 3 Glucagon
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cleaves proglucagon to form oxyntomodulin, glucagon-like peptide-1 (GLP-1) and GLP-2. The research group led by Roger Unger, a member of which was the master clinician Leonard Madison, developed the first radioimmunoassay for measuring blood glucagon
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Introduction Glucagon is a 29 amino acid pancreatic peptide hormone secreted by the pancreatic alpha cells. It is derived from the precursor hormone proglucagon, which is also a precursor for glucagon-like gut peptides ( Sandoval & D
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Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden
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CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
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islets ( Xin et al. 2016 ). It will be possible to address this discrepancy by direct amperometric detection of acetylcholine release ( Keighron et al. 2015 ) from α-cells at single-cell resolution. In addition, glucagon-like peptide 1 (GLP-1) was
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al. 2018 , Dai et al. 2022 ). Incretin peptides are secreted by enteroendocrine cells in the intestine and peptides such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have also been implicated in the