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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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disadvantageous regulatory mechanisms in a cell-targeted, pathophysiology-specific manner. This review aims to outline the current understanding of signaling bias at the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) in three broad categories: (i) ligand