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Beta-cell function and human islet transplantation: can we improve?

Jennifer Chen

Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton

Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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regimen ( Brennan et al. 2016 ). This glucocorticoid-free protocol with low dose tacrolimus (a calcineurin inhibitor (CNI)), sirolimus (a mTOR (mechanistic target of rapamycin, previously called the mammalian target of rapamycin) inhibitor) and an