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The gut microbiome, endocannabinoids and metabolic disorders

Fabio Arturo Iannotti

Fabio Arturo Iannotti Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Campania, Italy

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and

Vincenzo Di Marzo

Vincenzo Di Marzo Director, Joint International Research Unit for the Chemical and Biomolecular Study of the Microbiome in Metabolic Health and Nutrition (JIRU-MicroMeNu) between the Consiglio Nazionale delle Ricerche (CNR, Institute of Biomolecular Chemistry) and Université Laval, Naples, Campania, Italy
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada

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levels. Hypothalamic and peripheral eCB levels are also increased during obesity ( Di Marzo et al. 2001 , Cristino et al. 2013 , Morello et al. 2016 ), often in association with dysfunction of leptin, insulin and glucocorticoid signalling, thus