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RISING STARS: Approaches to modeling placental function in preeclampsia in vitro and in vivo

Jessica Milano-Foster

Jessica Milano-Foster Division of Animal Sciences, 245 Bond Life Sciences Center, 1201 Rollins Dr University of Missouri, Columbia, Missouri, USA

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Laura C Schulz

Laura C Schulz Department of Obstetrics, Gynecology and Women’s Health, N610 Medical Sciences Building, Columbia, Missouri, USA

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described by the two-stage model ( Redman 1991 , Staff 2019 ) in which a first stage of placental oxidative stress leads to the release of factors that result in a second stage of systemic endothelial dysfunction and end-organ damage ( Fig. 1 ). Stage 1 can