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excess status linked to T2DM Supplementation: ↓BW, adiposity, liver weight ↑blood thyroid hormone (TSH, TT3, FT3, FT4) High I dose: Pancreatic destruction, hyperglycemia Impair beta cell insulin secretion, apoptosis Selenium (Se) Male: 55 µg
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
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Department of Medicine, University of Toronto, Toronto, ON, Canada
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Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada
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understood. Our current understanding of the regulation of maternal glucose metabolism during pregnancy A number of placental hormones contribute to the changes in maternal insulin sensitivity and secretion, as reviewed elsewhere ( Napso et al. 2018
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-inducing hormones peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) ( da Silva et al. 2020 ). In this context, the modulation of gut microbiota by promoting the growth of some specific bacteria by a prebiotic approach can be an effective strategy to reverse
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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intestinal homeostasis (gut microbiota composition and gut barrier function) directly or indirectly (via microbial-produced metabolites) disturbs the production and secretion of gut endocrine hormones, thereby triggering metabolic diseases ( Fig. 2 ). The
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Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada
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depending on the human cohort investigated and several genetic, developmental, hormonal, lifestyle and environmental factors (e.g. maternal diet during gestation and lactation, type of delivery, sex, age, diet, geographical location, circadian rhythms