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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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. GLP-1R agonism in hypothalamic neurons causes a decrease in food intake and eventually body weight. It is apparent that GLP-1R action in the hypothalamus is, in part, mediated by the role of Gαs, while the roles of Gq and β-arrestin are unclear