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Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland
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Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland
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profound insulin resistance with features of the ‘insulin resistance syndrome’. The large remaining group of T2D is still highly heterogeneous in terms of clinical characteristics, disease progression, treatment responses and risk of complications. Even
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), involving alterations in both insulin secretion and insulin sensitivity (the effectiveness of insulin): some individuals show a severe loss of insulin secretion, whereas others show obesity, insulin resistance and hyperinsulinemia, albeit insufficient to
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Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia
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( Van Assche et al. 1978 , Parsons et al. 1992 , Butler et al. 2010 ). Normal pregnancy is a state of insulin resistance, particularly in the third trimester when some women develop gestational diabetes. Women who maintain normal glucose
