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Not the second fiddle: α cell development, identity, and function in health and diabetes

Elliott P Brooks

Elliott P Brooks Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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Lori Sussel

Lori Sussel Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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30 days post β-cell ablation. Gene expression changes in these α cells consist of genes related to proliferation, mTOR signaling, cell cycle regulators, and interferon signaling but also many transcription factors and genes related to β cell identity