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100 years of insulin: A special collection x

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100 YEARS OF INSULIN: Pancreas pathology in type 1 diabetes: an evolving story

Sarah J Richardson

Sarah J Richardson Islet Biology Group, Exeter Centre for Excellence in Diabetes (EXCEED), Institute of Biomedical and Clinical Sciences (IBCS), University of Exeter, RILD Level 4, Exeter, UK

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Alberto Pugliese

Alberto Pugliese Division of Diabetes Endocrinology and Metabolism, Departments of Medicine, Microbiology and Immunology, Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA

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in the T1D pancreas, but not in IDIs or in control pancreas ( Colli et al. 2018 , Osum et al. 2018 ). PDL1 expression in beta cells has been linked to interferon alpha and gamma, in the context of alterations induced by islet inflammation, and is

Article Type:: Review Article

Collections:: 100 years of insulin: A special collection, Top-cited articles of 2023

DOI:: https://doi.org/10.1530/JOE-21-0358

Volume/Issue:: Volume 252: Issue 2

Free access

100 YEARS OF INSULIN: Arresting or curing type 1 diabetes: an elusive goal, but closing the gap

Pieter-Jan Martens

Pieter-Jan Martens Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Conny Gysemans

Conny Gysemans Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Chantal Mathieu

Chantal Mathieu Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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profiles was also detected in the peripheral blood as both pro-inflammatory (defined by multi-autoantibody and interferon-(IFN)-γ positivity) and controlled (defined by pauci-autoantibody and interleukin (IL)-10 positivity) responses were observed in newly