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Lauren Brady Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington, USA

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Peter S Nelson Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, Washington, USA
Division of Medical Oncology, University of Washington, Seattle, Washington, USA

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from the surrounding microenvironment recruits macrophages, and neutrophils to the tumor which can contribute to aggressive tumor behavior and increased invasive potential ( Marques et al. 2019 ). Subsets of immune cells thought to closely interact

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Jessica Milano-Foster Division of Animal Sciences, 245 Bond Life Sciences Center, 1201 Rollins Dr University of Missouri, Columbia, Missouri, USA

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Laura C Schulz Department of Obstetrics, Gynecology and Women’s Health, N610 Medical Sciences Building, Columbia, Missouri, USA

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attributable to immune activation, including cytokine release, natural killer cell and macrophage activation, and activation of complement ( Clark et al. 1998 ). However, the lack of conclusive evidence for hypertension suggests that immune incompatibility

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