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The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
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Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China
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Introduction As a core reproductive organ, the ovary has two unique functions: producing mature oocytes for fertilization and secreting sex hormones for maintaining the normal activities of multiple organs, including itself. The normal
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controlled trials have tested supplementing selenium in patients with polycystic ovary syndrome, cardiovascular disease, and diabetes, but the effects of supplementation on metabolic parameters such as glucose tolerance, insulin sensitivity, beta
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conditions such as cancer, non-alcoholic fatty liver disease and polycystic ovary disease, although clinical evidence supporting the use of metformin in these diseases is scant ( Marshall 2017 ). It has also been proposed as a general 'anti-ageing' drug based