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Lucia Gajdosechova Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Katarina Krskova Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Ana Belen Segarra Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Andrea Spolcova Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Maciej Suski Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Rafal Olszanecki Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Stefan Zorad Institute of Experimental Endocrinology, Unit of Physiology, Institute of Organic Chemistry and Biochemistry, Chair of Pharmacology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia

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Introduction The neuropeptide oxytocin is a hormone with a wide range of central and peripheral effects. Besides its well-known role in labour and lactation ( Gimpl & Fahrenholz 2001 ), oxytocin is released in response to various stress stimuli

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Gareth Leng Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH9 8XD, UK

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Rafael Pineda Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH9 8XD, UK

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Nancy Sabatier Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH9 8XD, UK

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Mike Ludwig Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH9 8XD, UK

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stimulation of the neural stalk in lactating rabbits resulted in a sharp rise in intramammary pressure, and they inferred that this was the consequence of oxytocin secreted from the posterior pituitary. They noted that the response to stimulation depended

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Mone Zaidi The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Maria I New The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Harry C Blair The Pittsburgh VA Medical Center and Departments of Pathology and of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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Alberta Zallone Department of Histology, University of Bari, Bari, Italy

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Ramkumarie Baliram The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Terry F Davies The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Christopher Cardozo The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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James Iqbal The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Li Sun The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Clifford J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

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Tony Yuen The Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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Argiolas A Collu M Gessa GL Melis MR Serra G 1988 The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats . European Journal of Pharmacology 149 389 – 392 . ( https://doi.org/10

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Elena Conte Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Adele Romano Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Michela De Bellis Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Marialuisa de Ceglia Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Maria Rosaria Carratù Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

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Silvana Gaetani Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy

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Fatima Maqoud Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Domenico Tricarico Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy

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Claudia Camerino Department of Pharmacy–Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy
Department of Physiology and Pharmacology ‘V. Erspamer’, SAPIENZA University, Rome, Italy
Department of Biomedical Sciences and Human Oncology (Section of Pharmacology), School of Medicine, University of Bari, Bari, Italy

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Introduction The neuropeptide oxytocin (Oxt) is a hormone/neurotransmitter with both central and peripheral effects. Oxt neurons are located in the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus. The peripheral Oxt is

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Tatiane Vilhena-Franco Department of Physiology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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André Souza Mecawi Department of Physiological Sciences, Institute of Biological and Healthy Sciences, Federal Rural University of Rio de Janeiro, Seropédica, Rio de Janeiro, Brazil
Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

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Lucila Leico Kagohara Elias Department of Physiology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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José Antunes-Rodrigues Department of Physiology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

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experimental model extensively used to study these responses. WD increases osmolality and decreases plasma volume, inducing the release of hormones that act to maintain homeostasis, such as vasopressin (AVP) and oxytocin (OT), and the activation of the renin

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Eriko Furube Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Tetsuya Mannari Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Shoko Morita Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan
Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Kazunori Nishikawa Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Ayaka Yoshida Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Masanobu Itoh Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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Seiji Miyata Department of Applied Biology, Department of Anatomy and Neuroscience, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

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arginine vasopressin (AVP) and oxytocin (OXT) into the blood circulation from their axonal terminals ( Miyata & Hatton 2002 ). Similarly, they release a variety of neuropeptides into the blood circulation at the median eminence (ME) to control secretion of

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Galit Levi Dunietz Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Lucas J Tittle Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA

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Sunni L Mumford Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Louise M O’Brien Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA

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Ana Baylin Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA

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Enrique F Schisterman Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Ronald D Chervin Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA

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Larry J Young Center for Translational Social Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA

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improved cardiovascular health, cognition, as well as anxiety and depressive behaviors ( Walf et al. 2009 , Ramírez-Hernández et al. 2024 ). Oxytocin (OT) is a hypothalamic neuropeptide hormone and neuromodulator involved in reproductive physiology

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M. Y. DAWOOD
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K. S. RAGHAVAN
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C. POCIASK
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The evaluation of a radioimmunoassay of oxytocin is described. The method involved careful collection and transportation of blood at 4 °C, acidification of the plasma, extraction with Fuller's earth and radioimmunoassay using antisera raised in rabbits immunized against oxytocin conjugated to bovine serum albumin and 125I-labelled oxytocin. The antisera showed insignificant cross-reaction with a variety of small peptides including vasopressin and vasotocin. The limit of detection of the assay was 2·5 pg with intra-assay and interassay coefficients of variation of 7–15% and 12–18% respectively. Seventy-seven per cent (88 out of 116) of the pregnant women tested had detectable maternal plasma oxytocin. Serial samples of maternal plasma showed a significant increase in oxytocin from the first to the second stage of labour and a significant decrease in the third stage. Oxytocin concentrations in the umbilical arterial plasma were significantly higher in patients in labour. The significance of these findings is discussed.

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EWA BRZEZIŃSKA-ŚLEBODZIŃSKA
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SUMMARY

The oxytocin-inactivating activity (OIA) of liver, kidney, uterus, pancreas, spleen and duodenum homogenates of hens was studied. The first-order constant of oxytocin inactivation was higher in the liver and pancreas than in the uterus and kidney or in the duodenum and spleen. Using synthetic analogues of oxytocin (deamino-oxytocin, deamino-carba1-oxytocin and carba1-oxytocin the mechanism of enzymic inactivation of oxytocin by hen tissue was investigated.

Enzymic hydrolysis by the CH2-terminal cleavage was most marked in duodenum (about 86% OIA) and kidney (54·8% OIA). Reduction of the disulphide bridge was most marked in the uterus (about 80% OIA) and pancreas (about 73% OIA). Splitting by non-specific aminopeptidases after reduction of the disulphide bridge occurred mainly in the liver (72% OIA) and in the spleen (44% OIA).

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H. D. Nicholson
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S. E. F. Guldenaar
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G. J. Boer
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B. T. Pickering
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ABSTRACT

The long-term effects of oxytocin administration on the testis were studied using intratesticular implants. Adult male rats had an Accurel device containing 20 μg oxytocin (releasing approximately 200 ng/day) implanted into the parenchyma of each testis; control animals received empty devices. The animals were killed at weekly intervals for 4 weeks. Some animals were perfused and the testes processed for light and electron microscopy. Blood was collected from the remaining animals for the measurement of testosterone, dihydrotestosterone, LH, FSH and oxytocin; epididymal sperm counts were measured and the testes were extracted and radioimmunoassayed for testosterone, dihydrotestosterone and oxytocin.

Long-term administration of oxytocin resulted in a significant reduction in testicular and plasma testosterone levels throughout the 4-week period examined and, after 14 days of treatment, lipid droplets were seen in the Leydig cells of treated but not control animals. Concentrations of dihydrotestosterone in the plasma and testes of the oxytocin-treated animals, however, were significantly elevated after 7 and 14 days and at no time fell below control values. Plasma FSH levels were also lower in the oxytocin-treated animals. Intratesticular oxytocin treatment did not affect LH or oxytocin concentrations in the plasma, epididymal sperm counts or the number of Leydig cells in the testis. Empty Accurel devices had no effect on testicular morphology.

This study provides the first evidence that oxytocin in vivo can modify steroidogenesis in the testis.

Journal of Endocrinology (1991) 130, 231–238

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