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its mysteries has been progressing in recent years. A review from Western Australia emphasises that oxidative stress may be a main peripheral pathogenic mediator, and central regulation with sensitisation of pain requires further examination ( Ye et
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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, coagulation, and pain. Finally, loss of ACE2’s actions in the intestine may cause diarrhoea, nausea, and vomiting, by promoting inflammation and altering the microbiome. Adapted from American Journal of Pathology , volume 191, Ramos SG, Cruz Rattis BA de
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Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia
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. The disease often manifests as morning pain and stiffness in the metacarpophalangeal and metatarsophalangeal joints in a symmetrical pattern. Patients also present with abnormally high levels of autoantibodies including rheumatoid factor (RF) and anti