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Emma J Hamilton Medical School, University of Western Australia, Fiona Stanley Hospital, Murdoch and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

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Stephen M Twigg Central Clinical School, Sydney Medical School, the Faculty of Medicine and Health, University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

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its mysteries has been progressing in recent years. A review from Western Australia emphasises that oxidative stress may be a main peripheral pathogenic mediator, and central regulation with sensitisation of pain requires further examination ( Ye et

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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, coagulation, and pain. Finally, loss of ACE2’s actions in the intestine may cause diarrhoea, nausea, and vomiting, by promoting inflammation and altering the microbiome. Adapted from American Journal of Pathology , volume 191, Ramos SG, Cruz Rattis BA de

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Eugenie Macfarlane Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Hong Zhou Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia

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Markus J Seibel Bone Research Program, ANZAC Research Institute, The University of Sydney, Australia
Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, Australia

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. The disease often manifests as morning pain and stiffness in the metacarpophalangeal and metatarsophalangeal joints in a symmetrical pattern. Patients also present with abnormally high levels of autoantibodies including rheumatoid factor (RF) and anti

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