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Dong-Xu Han Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Chang-Jiang Wang Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Xu-Lei Sun Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Jian-Bo Liu Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Hao Jiang Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Yan Gao Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Cheng-Zhen Chen Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Bao Yuan Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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Jia-Bao Zhang Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, People’s Republic of China

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effects of circRNAs on reproductive hormones in rats is limited. In this study, we systematically investigated the circRNA content in the immature (D15) and mature (D120) rat anterior pituitary using the Illumina platform. Our findings will provide a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0540
Volume/Issue:
Volume 240: Issue 3
Free access
Lei Du State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Yang Wang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Cong-Rong Li State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Liang-Jian Chen State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Jin-Yang Cai State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Zheng-Rong Xia Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Wen-Tao Zeng Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Zi-Bin Wang Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Xi-Chen Chen Analysis and Test Center, Nanjing Medical University, Nanjing, Jiangsu, China

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Fan Hu State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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Dong Zhang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China

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Xiao-Wei Xing The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

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Zhi-Xia Yang State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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females, suggesting that BAT dysfunction might be an important cause of PCOS and that BAT supply might help to cure PCOS. In fact, rat-to-rat BAT transplantation was recently tested in a rat PCOS model. The strategy significantly improved the endocrine

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JOE-20-0068
Volume/Issue:
Volume 248: Issue 2
Restricted access
Marlise Guerrero Schimpf Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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María M Milesi Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Enrique H Luque Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Jorgelina Varayoud Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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low dose (2 mg/kg of body weight (bw)/day) of a GBH during the first postnatal days (PND) alters the development of the rat uterus by affecting uterine morphology and the expression of proteins that regulate uterine organogenetic differentiation during

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0207
Volume/Issue:
Volume 239: Issue 2
Free access
Sjoerd D Joustra Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Onno C Meijer Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Charlotte A Heinen Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Isabel M Mol Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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El Houari Laghmani Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Rozemarijn M A Sengers Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Gabriela Carreno Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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A S Paul van Trotsenburg Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Nienke R Biermasz Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Daniel J Bernard Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Jan M Wit Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Wilma Oostdijk Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Ans M M van Pelt Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Geert Hamer Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Gerry T M Wagenaar Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands

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temporal patterns of IGSF1 protein and mRNA expression in the rat. Materials and methods Animals The research protocol was approved by the Institutional Animal Care and Use Committees of the Leiden University Medical Center and the Academic Medical Center

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0204
Volume/Issue:
Volume 226: Issue 3
Free access
Martina Holubová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Jana Zemenová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic

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Barbora Mikulášková Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Vladimíra Panajotova Apigenex Limited, Prague, Czech Republic

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Jiří Stöhr Apigenex Limited, Prague, Czech Republic

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Martin Haluzík First Faculty of Medicine, Charles University, Prague, Czech Republic

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Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Železná Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Lenka Maletínská Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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standard diet. In addition to the DIO rat model, the Zucker diabetic rat model, which is a model with impaired leptin receptor signaling ( Fellmann et al . 2013 ), is frequently used for studying the potential of anti-obesity and anti-diabetic peptidic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0519
Volume/Issue:
Volume 229: Issue 2
Free access
E M de Vries Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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H C van Beeren Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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M T Ackermans Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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A Kalsbeek Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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E Fliers Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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A Boelen Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

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TH metabolism in the rat liver. Besides an enhanced metabolism of TH in peripheral tissues via altered deiodinases, sequestration of TH in tissues is also suggested to play a role in the decreased serum TH concentrations. In order to enter the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0533
Volume/Issue:
Volume 224: Issue 1
Free access
Emily Panagiotidou Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Sophia Zerva Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Dimitra J Mitsiou Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Michael N Alexis Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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Efthymia Kitraki Department of Basic Sciences and Oral Biology, Institute of Biology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, 11527 Athens, Greece

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according to a split litter design. In some groups, more than one rat of the same sex and the same litter was included and this was taken into consideration for statistical analyses (litter effect). Four to six animals per group were killed by decapitation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0416
Volume/Issue:
Volume 220: Issue 3
Free access
Nathalie Marissal-Arvy INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Rachel Hamiani INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Emmanuel Richard INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Marie-Pierre Moisan INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Véronique Pallet INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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from cholesterol by vitamin A deficiency in rat adrenals ( Juneja et al . 1966 ). Furthermore, RA treatment was shown to inhibit corticosterone (CORT) production in experimental Cushing's syndrome ( Paez-Pereda et al . 2001 ). The inhibitory effect of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0062
Volume/Issue:
Volume 219: Issue 1
Free access
Ivana Vaněčková Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Lenka Maletínská Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Michal Behuliak Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Veronika Nagelová Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Josef Zicha Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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Jaroslav Kuneš Institute of Physiology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic

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would also like to discuss some information about epigenetic inheritance, which should partially explain the gene–environment interaction. Rat models of obesity and hypertension Animal models are essential to understand the pathophysiology of human

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0368
Volume/Issue:
Volume 223: Issue 3
Free access
Daniel Landau
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Chen Chayat Department of Pediatrics A, Shraga Segal Department of Microbiology and Immunology, Department of Pathology, Laboratory for Molecular Medicine and Israeli Rat Genome Center, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University, PO Box 151, Beer Sheva 84101, Israel

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Nili Zucker
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Eli Golomb Department of Pediatrics A, Shraga Segal Department of Microbiology and Immunology, Department of Pathology, Laboratory for Molecular Medicine and Israeli Rat Genome Center, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University, PO Box 151, Beer Sheva 84101, Israel

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Channa Yagil Department of Pediatrics A, Shraga Segal Department of Microbiology and Immunology, Department of Pathology, Laboratory for Molecular Medicine and Israeli Rat Genome Center, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University, PO Box 151, Beer Sheva 84101, Israel

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Yoram Yagil Department of Pediatrics A, Shraga Segal Department of Microbiology and Immunology, Department of Pathology, Laboratory for Molecular Medicine and Israeli Rat Genome Center, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University, PO Box 151, Beer Sheva 84101, Israel

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Yael Segev Department of Pediatrics A, Shraga Segal Department of Microbiology and Immunology, Department of Pathology, Laboratory for Molecular Medicine and Israeli Rat Genome Center, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University, PO Box 151, Beer Sheva 84101, Israel

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Sabra rat model. This model consists of two strains: the Sabra hypertension-prone (SBH/y) rats that remain normotensive when fed regular diet but become hypertensive when salt loaded, and the Sabra hypertension-resistant (SBN/y) rats that remain

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0040
Volume/Issue:
Volume 197: Issue 1
Free access