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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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-arrestin recruitment ( Darbalaei et al. 2020 ). Cotadutide is a less potent and less effective insulin secretagogue in studies using rat insulinoma cells ( Henderson et al. 2016 ), yet in vivo treatment with the compound improves glucose control further than