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The gut microbiome, endocannabinoids and metabolic disorders

Fabio Arturo Iannotti

Fabio Arturo Iannotti Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Campania, Italy

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and

Vincenzo Di Marzo

Vincenzo Di Marzo Director, Joint International Research Unit for the Chemical and Biomolecular Study of the Microbiome in Metabolic Health and Nutrition (JIRU-MicroMeNu) between the Consiglio Nazionale delle Ricerche (CNR, Institute of Biomolecular Chemistry) and Université Laval, Naples, Campania, Italy
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Department of Medicine, Faculty of Medicine and School of Nutrition, Faculty of Agricultural and Food Sciences, CRIUCPQ, INAF and Centre NUTRISS, Université Laval, Québec City, Canada

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acid amides, such as the sleep-inducing factor, oleamide, a FAAH substrate that was suggested to activate CB1 ( Leggett et al. 2004 ), and, like some unsaturated NAEs, to antagonise the transient receptor potential vanilloid type-2 (TRPV2) channel