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Elliott P Brooks Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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Lori Sussel Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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the content of the review. We also thank Dylan Sarbaugh and Cell, Stem Cell and Development Program graduate students for their critical reading of the manuscript. References Ackermann AM Wang Z Schug J Naji A & Kaestner KH 2016

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Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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-like cells derived from embryonic stem (ES) cells, though there are notable exceptions ( Li et al. 2020 , Sachs et al. 2020 , Weng et al. 2020 , Tritschler et al. 2022 ). While the function of many of these α cell-specific or ‘identity’ genes has

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R Paul Robertson Nutrition Department of Internal Medicine, Division of Metabolism Endocrinology, University of Washington, Seattle, Washington, USA

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pancreatectomy. These issues surrounding the use of the liver as a transplantation site have important implications for fields developing other more experimental approaches to the restoration of islet function that propose using stem cell and xenogenic animal

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Jasleen Kaur Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Elizabeth R Seaquist Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Introduction Glucagon is a 29 amino acid pancreatic peptide hormone secreted by the pancreatic alpha cells. It is derived from the precursor hormone proglucagon, which is also a precursor for glucagon-like gut peptides ( Sandoval & D

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