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asprosin mediated inhibition of adipose browning To uncover the underlying mechanism of the aforementioned observations, we explored whether Nrf2, a crucial antioxidant transcription factor, was involved in the process. Nrf2 is a transcription factor
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action. This includes activation of Dicer, iPFK2 and miRNA leading to lower expression of several pro-inflammatory cytokines such as TNF-α and IL-6. AMPK, AMP kinase; ATF3, activating transcription factor 3; ChREBP, carbohydrate-responsive element
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through the GHR/janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 b (STAT5b) pathway to maintain hepatic expression of insulin-like growth factor 1 (IGF1; Rotwein 2012 , Feigerlova et al. 2013 ), where hepatic IGF1 represents >80
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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European Associated Laboratory (EAL) ‘NeuroMicrobiota’, Brussels/Toulouse, Belgium
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Introduction Obesity is linked with many cardiometabolic risk factors, such as insulin resistance, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). Although lowering body weight is effective for alleviating several of these
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uptake, and by inhibiting the expression of FOXO transcription factors, gluconeogenic enzymes (phosphoenolpyruvate, glucose-6-phosphatase), and negative regulators of PI3K/Akt signaling like phosphatase and tensin homolog protein (PTEN) ( Cameron et al
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Division of Advanced Diagnostics, Toronto General Research Institutes, University Health Network, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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/or function. Pancreatic duodenal homeobox (PDX-1) and NK6 homeobox 1 (Nkx6.1) are two widely studied transcription factors that regulate pancreatic ontogeny and fetal β-cell development ( Baeyens et al. 2018 ). In particular, PDX-1, also known as insulin
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
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Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China
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physiology of the ovary is controlled by the hypothalamus–pituitary–ovarian axis (HPO axis). Many genetic and environmental pathological factors affect ovarian function, causing subfertility or infertility. Thus, alterations in ovarian endocrine activity will
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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were restored in clock deficient mice when fed under TRF ( Vollmers et al . 2009 , Chaix et al . 2019 ). This suggests that TRF impacts other regulatory factors that drive rhythmic transcriptomes, independently of clock. NAD is a cofactor that plays