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Esteban Grasso
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Daniel Paparini
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Mariana Agüero Immunopharmacology Laboratory, School of Sciences, Obstetrics, School of Sciences, University of Buenos Aires and IQUIBICEN- CONICET (National Research Council of Science and Technology), Int. Guiraldes 2160, Ciudad Universitaria, Pabellón 2 Piso 4, Buenos Aires C1428EHA, Argentina

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Gil Mor Immunopharmacology Laboratory, School of Sciences, Obstetrics, School of Sciences, University of Buenos Aires and IQUIBICEN- CONICET (National Research Council of Science and Technology), Int. Guiraldes 2160, Ciudad Universitaria, Pabellón 2 Piso 4, Buenos Aires C1428EHA, Argentina

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Claudia Pérez Leirós
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Rosanna Ramhorst
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-privileged site supporting the nidation of a semiallogenic fetus ( Gellersen & Brosens 2003 , Mesiano et al . 2011 ). The decidualization of the stromal cells also occurs in the absence of pregnancy and the declining P 4 levels trigger several effects, such as

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Jie Liu College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Department of Biology, Shantou University, Shantou, China

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Fei Gao Department of Biology, Shantou University, Shantou, China

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Yue-Fang Liu College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Hai-Ting Dou College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Jia-Qi Yan College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Zong-Min Fan College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Zeng-Ming Yang College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Introduction Embryo implantation is the attachment of the embryo to the uterine luminal epithelium followed by invasion of embryos into the underlying stromal bed. Once embryos are implanted, uterine stromal cells will undergo decidualization

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Yan Su Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Sujuan Guo Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Chunyan Liu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Na Li Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Shuang Zhang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yubin Ding Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xuemei Chen Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Junlin He Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xueqing Liu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yingxiong Wang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Rufei Gao Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Introduction In mammals, the reproductive process represents a complex and highly coordinated biological phenomenon, which involves embryo implantation, decidualization and placental development ( Cakmak & Taylor 2011 , Hemberger et al

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Wenqi Chen Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Siyu Lu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Chengshun Yang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Na Li Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xuemei Chen Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Junlin He Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xueqing Liu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yubin Ding Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Chao Tong Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chuan Peng Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Chen Zhang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Yan Su Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yingxiong Wang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Rufei Gao Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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regulatory effects of high-level insulin on the endometrium. Our previous study found that high levels of insulin could result in impaired endometrial receptivity and further affect endometrial decidualization in early pregnant mice ( Li et al. 2017

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Amanda L Patterson Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA

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Jamieson Pirochta Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA

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Stephanie Y Tufano Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA

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Jose M Teixeira Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA

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Introduction Two of the most crucial events in early pregnancy in species with invasively implanting embryos, such as humans and mice, are embryo implantation and endometrial decidualization. Embryo implantation is a tightly regulated series

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Vinay Shukla Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India

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Jyoti Bala Kaushal Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India

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Pushplata Sankhwar Department of Obstetrics and Gynecology, King George’s Medical University, Lucknow, India

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Murli Manohar Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India

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Anila Dwivedi Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India

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Introduction Decidualization of endometrial stromal cells (ESCs) is the hallmark of tissue remodeling which supports embryo implantation and proper placental development ( Gellersen & Brosens 2014 , Yu et al. 2017 , Liu et al. 2017

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Ying Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China
Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Nan Meng Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haili Bao Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Yufei Jiang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Ningjie Yang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Kejia Wu Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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Jinxiang Wu Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China

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Haibin Wang Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Shuangbo Kong Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, Fujian, China
Reproductive Medical Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

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Yuanzhen Zhang Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, China

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transformation process involving a proliferation-differentiation transition that is defined as decidualization ( Gellersen & Brosens 2014 ) and is sustained by elevated P 4 levels in the luteal phase ( Gellersen & Brosens 2003 ). It has been confirmed that

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Hai-Fan Yu College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China

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Zhan-Peng Yue College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China

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Kai Wang College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China

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Zhan-Qing Yang College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China

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Hong-Liang Zhang College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China

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Shuang Geng College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China

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Bin Guo College of Veterinary Medicine, Jilin University, Changchun, People’s Republic of China

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Introduction Decidualization, a process where uterine stromal cells undergo extensive proliferation and differentiation into decidual cells, is essential for continued embryonic development and successful pregnancy ( Dey et al . 2004 , Zhang

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Jiju Wang Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China

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Yunhui Tang Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China

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Songcun Wang Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China

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Liyuan Cui Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China

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Dajin Li Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China

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Meirong Du Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, People’s Republic of China

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had not been reported. Endometrial decidualization is an important step in embryonic development and fetal growth. In particular, this process is critical in establishing maternal–fetal communication and provide a good nutritional environment for

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Dang-Dang Li College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Ying-Jie Gao College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Xue-Chao Tian College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Zhan-Qing Yang College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Hang Cao College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Qiao-Ling Zhang College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Bin Guo College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Zhan-Peng Yue College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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be regulated by Hoxa10 gene, which was essential for decidualization ( Benson et al . 1996 , Germeyer et al . 2009 , Doherty et al . 2011 , Zhang et al . 2013 ). According to our (B Guo and X-C Tian unpublished observations) microarray data

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