Search Results
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Search for other papers by Marc Schneeberger in
Google Scholar
PubMed
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Search for other papers by Ramon Gomis in
Google Scholar
PubMed
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Search for other papers by Marc Claret in
Google Scholar
PubMed
energy balance through behavioral, autonomic, and endocrine outputs. These sophisticated biological programs are influenced by multiple factors, including environmental, genetic, and epigenetic mechanisms. The immense complexity of these systems
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Search for other papers by Ruben Nogueiras in
Google Scholar
PubMed
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Search for other papers by Sulay Tovar in
Google Scholar
PubMed
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Search for other papers by Sharon E Mitchell in
Google Scholar
PubMed
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Search for other papers by Perry Barrett in
Google Scholar
PubMed
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Search for other papers by D Vernon Rayner in
Google Scholar
PubMed
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Search for other papers by Carlos Dieguez in
Google Scholar
PubMed
Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Search for other papers by Lynda M Williams in
Google Scholar
PubMed
hypothalamus ( Graham et al. 2003 ). These nuclei are important in controlling circadian rhythms, appetite and energy balance ( Takahashi & Zatz 1982 , Williams et al. 2001 ). In contrast, NMU expression in the rat is limited to the SCN, relatively few
Search for other papers by Pryscila D S Teixeira in
Google Scholar
PubMed
Search for other papers by Angela M Ramos-Lobo in
Google Scholar
PubMed
Search for other papers by Mariana Rosolen Tavares in
Google Scholar
PubMed
Search for other papers by Frederick Wasinski in
Google Scholar
PubMed
Search for other papers by Renata Frazao in
Google Scholar
PubMed
Search for other papers by Jose Donato Jr in
Google Scholar
PubMed
intake and expenditure ( Ramos-Lobo & Donato 2017 ). Thus, genetic mutations that cause the absence of leptin or the leptin receptor (LepR) produce metabolic changes that resemble those observed during intense negative energy balance, including hunger and
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Search for other papers by Sharon E Mitchell in
Google Scholar
PubMed
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Search for other papers by Ruben Nogueiras in
Google Scholar
PubMed
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Search for other papers by Kellie Rance in
Google Scholar
PubMed
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Search for other papers by D Vernon Rayner in
Google Scholar
PubMed
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Search for other papers by Sharon Wood in
Google Scholar
PubMed
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Search for other papers by Carlos Dieguez in
Google Scholar
PubMed
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
Search for other papers by Lynda M Williams in
Google Scholar
PubMed
Introduction Studies of rodents with either single gene mutations or gene knockouts have led to the discovery of a number of key components of the hypothalamic appetite and energy balance control system ( Williams et al. 2001
Search for other papers by Shin-ya Ueda in
Google Scholar
PubMed
Search for other papers by Takahiro Yoshikawa in
Google Scholar
PubMed
Search for other papers by Yoshihiro Katsura in
Google Scholar
PubMed
Search for other papers by Tatsuya Usui in
Google Scholar
PubMed
Search for other papers by Hayato Nakao in
Google Scholar
PubMed
Search for other papers by Shigeo Fujimoto in
Google Scholar
PubMed
variations in appetite and post-exercise energy intake (EI), leading to negative energy balance (EB; Blundell & King 1998 , Hubert et al . 1998 ). Recently, there has been growing concern that appetite and energy homeostasis are controlled by a variety of
Search for other papers by K Scrimgeour in
Google Scholar
PubMed
Search for other papers by M J Gresham in
Google Scholar
PubMed
Search for other papers by L R Giles in
Google Scholar
PubMed
Search for other papers by P C Thomson in
Google Scholar
PubMed
Search for other papers by P C Wynn in
Google Scholar
PubMed
Search for other papers by R E Newman in
Google Scholar
PubMed
remaining one-third from the small intestine ( Peeters 2005 ). Ghrelin has been shown to have numerous physiological functions that affect energy balance ( Horvath et al . 2001 , Govoni et al . 2005 ), gastrointestinal motility and secretion ( Masuda et
Search for other papers by Christian Doyon in
Google Scholar
PubMed
Search for other papers by Pierre Samson in
Google Scholar
PubMed
Search for other papers by Josée Lalonde in
Google Scholar
PubMed
Search for other papers by Denis Richard in
Google Scholar
PubMed
of the CRF 1 receptor in the regulation of energy balance, these antagonists may also prove useful in the pharmacological treatment of obesity, especially in cases where obesity is associated with hyperactivity of the stress axis. Animal
Search for other papers by AR Assali in
Google Scholar
PubMed
Search for other papers by A Ganor in
Google Scholar
PubMed
Search for other papers by Y Beigel in
Google Scholar
PubMed
Search for other papers by Z Shafer in
Google Scholar
PubMed
Search for other papers by T Hershcovici in
Google Scholar
PubMed
Search for other papers by M Fainaru in
Google Scholar
PubMed
Weight reduction is recommended for the treatment of subjects with insulin resistance (IR) syndrome; however, the relative importance of the decrease in body fat or the negative energy balance achieved during a hypo-energetic diet in the improvement of this metabolic syndrome is still debated. Therefore, we undertook to study their relative impact on amelioration of the metabolic abnormalities associated with IR in obese subjects. Twelve obese subjects (six males and six females, mean+/-s.d. body mass index 36.1+/-4.7 kg/m(2)) aged 38-57 years were investigated. During the first phase they were fed a hypo-energetic diet for 6 weeks (week 0-6). During the second phase, lasting 4 weeks (week 6-10) they consumed an iso-energetic diet. During the third phase (week 10-16) the subjects were put again on a hypo-energetic diet. Insulin sensitivity (SI) was assessed by an insulin-enhanced, frequently sampled i.v. glucose tolerance test with minimal model analysis. All subjects reduced weight during both hypo-energetic periods: 5.49+/-0.75 and 2.32+/-0.37%, means+/-s.e.m., P<0.005, week 0-6 and 10-16 respectively. One-third of this loss was achieved within the first week of each period. SI increased by 353+/-121 and 147+/-38% (P<0.005), means+/-s.e.m., at the end of both hypo-energetic periods (week 6 vs 0 and 16 vs 10 respectively). Two-thirds of this improvement were observed within the first week of each period (week 1 vs 0 and 11 vs 10 respectively). During the iso-energetic weight-maintaining period (week 10 vs 6), SI decreased by 43.5+/-7.9% (P<0.002). Serum levels of leptin and triglyceride followed a similar pattern, but to a lesser extent. It may be concluded that negative energy balance is more effective when compared with maintaining a stable lower weight in achieving an improvement in the metabolic parameters of the IR syndrome.
Search for other papers by Edra London in
Google Scholar
PubMed
Search for other papers by Michelle Bloyd in
Google Scholar
PubMed
Search for other papers by Constantine A Stratakis in
Google Scholar
PubMed
1992 , Kim et al. 2018 ). Rare monogenic forms of obesity have facilitated much of our understanding about key molecular pathways involved in maintaining energy balance. Most of these regulatory pathways involve cyclic AMP (cAMP) signaling. The
Search for other papers by Victoria Diedrich in
Google Scholar
PubMed
Search for other papers by Elena Haugg in
Google Scholar
PubMed
Search for other papers by Carola Dreier in
Google Scholar
PubMed
Search for other papers by Annika Herwig in
Google Scholar
PubMed
: maintaining energy balance during winter. Studying seasonal adaptations of mammals is fascinating because they are very extreme, tightly regulated but also fully reversible. Understanding the underlying regulatory mechanisms will largely contribute to our
