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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines

Jonathan D Douros

Jonathan D Douros Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Jacek Mokrosinski

Jacek Mokrosinski Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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Brian Finan

Brian Finan Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, USA

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conformation has proven difficult. Additionally, there are classical challenges such as off-target selectivity, drug metabolism, and drug–drug interactions that are present with small molecule medicinal chemistry and development However, the parallel