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. 1978 , Maclaren et al. 1980 , Kava et al. 1992 , Shi et al. 1994 , Weksler-Zangen et al. 2001 ). Removal of testosterone from the sex-steroid milieu of the male animal improved insulin sensitivity in most studies, and thus was protective
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Centro de Biología Molecular ‘Severo Ochoa’, Departamento de Neuropatología Molecular CSIC-UAM, Madrid, Spain
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
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Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
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activates c-Src family tyrosine kinases . Molecular Cell 8 269 – 280 . ( https://doi.org/10.1016/S1097-2765(01)00304-5 ) 10.1016/S1097-2765(01)00304-5 11545730 Bourque M Dluzen DE Di Paolo T 2009 Neuroprotective actions of sex steroids in
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
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Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
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Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
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Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
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Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand
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peptide and the sex steroid increased the number of cells that secreted adrenomedullin, both hormones induced an increase in the mean level of expression of adrenomedullin mRNA (Fig. 5 ), the effect being statistically significant for testosterone
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Introduction Sex steroids are mainly synthesized by the gonads (testis and ovary), but the adrenals constitute an additional source ( Vanderschueren et al . 2004 , Callewaert et al . 2010 a ). Sex steroids are involved in the regulation of a
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Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland
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Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland
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Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland
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Introduction Imbalanced action of sex steroid hormones, i.e. androgens and estrogens, is involved in the pathogenesis of various severe diseases in humans. Hormone-dependent cancers are commonly lethal both in women and in men, with breast cancer
CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
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Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
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Introduction Sex steroids are key metabolic regulators in different tissues, with proven roles in the control of food intake and energy homeostasis, whose deregulation is frequently linked to the manifestation of diseases ( Mauvais-Jarvis et
National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA
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to direct hormonal regulation and were known as ‘un-inducible’ CYPs ( Daskalopoulos et al . 2012 b ). However, previous studies showed that sex steroid hormones affect the expression of CYP2D in the rat brain. In particular, testosterone treatment
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important to understand the physiological function of this highly restricted tissue-specific gene to gain insight into the physiological effects of sexual steroids in the kidney. In this report, we further explored the tissue distribution and sex-steroid
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enzymes whose activity is influenced by sex steroids ( Spike et al. 1992 , Gibson et al. 1999 , Coto-Montes et al. 2001 ). In fact, the female hamster has considerably more porphyrins than the male ( Spike et al. 1985 , 1986 ). These
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SUMMARY
The ovaries of the lungfish (Protopterus annectens Owen) were examined for sex steroids.
Extracts produced a positive response in the mouse uterine weight test. Processing by paper chromatographic methods indicated the presence of oestriol, oestrone, a trace of oestradiol-17β and progesterone, but not enough material was available for their definitive chemical demonstration. The possible significance of these results is discussed.